Even when right is all that's left: There are still more options for recovery from aphasia.

Even when right is all that's left: There are still more options for recovery from aphasia.
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DOI:
10.1002/ana.25217
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发表时间:
2018-04
影响因子:
11.2
通讯作者:
Schlaug G
Schlaug G
中科院分区:
医学1区
文献类型:
--
作者:
Schlaug G

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两个突出的假设告知了我们目前对大脑如何在损伤后恢复语言运动功能的理解:(1)募集病灶周围皮层以在受影响的半球中形成新的区域网络(病灶周围假设)(Fridriksson等人,2012; McKinnon等人,2017年),(2)未受损半球中的同伦区域和相关纤维束的接合,以促进言语运动功能的恢复(Geranmayeh等人,2014; Heiss和Thiel 2006; Zipse等人,2012; Pani等人,2016; Turkeltaub等人,2011; Xing等人,2016年),(3)两者的结合。这种“右移假说”是基于神经冗余理论,即两个半球都有能力支持言语运动功能(例如,Hickok和Poeppel 2004,2007; Saur等人,2006,2008; Marchina等人,2018),尽管左半球受损后右半球参与的程度可能因人而异,并且/或者取决于尚未完全理解的因素。在选择哪种途径以及哪种途径导致成功的潜在决定因素中,左半球病变的大小和部位以及弓状束(AF)或其他言语/语言相关结构的病变负荷(Marchina等人,2011; Hillis等人,右半球的募集(a)是否是“不完全恢复”或“不太有效的补偿”的标志(Heiss和Thiel,2006),(B)是否仅作为恢复过程中的短暂现象发生(Saur等人,2006年),或(c)表示使用内置冗余(Turkeltaub等人,2011; Marchina等人,2018; Ozdemir等人,2006年),以促进恢复的情况下,侮辱左半球仍然是一个有争议的问题。
Two prominent hypotheses inform our current understanding of how the brain recovers speech-motor function after an insult:(1) recruitment of perilesional cortex to form a new network of regions in the affected hemisphere (the perilesional hypothesis)(Fridriksson et al., 2012; McKinnon et al., 2017),(2) engagement of homotopic regions and associated fiber tracts in the undamaged hemisphere to facilitate recovery of speech-motor function (Geranmayeh et al., 2014; Heiss and Thiel 2006; Zipse et al., 2012; Pani et al., 2016; Turkeltaub et al., 2011; Xing et al., 2016), and (3) a combination of both. This “right-shift hypothesis” is based on the neural redundancy theory that both hemispheres have the capacity to support speech-motor function (eg, Hickok and Poeppel 2004, 2007; Saur et al., 2006, 2008; Marchina et al., 2018), although the degree to which the right hemisphere becomes involved after damage to the left may differ from person to person and/or depend upon factors that are not yet fully understood. Among the potential determinants of which route is chosen and which leads to success, size and site of left-hemisphere lesions and lesion load of the arcuate fasciculus (AF) or other speech/language-relevant structures (Marchina et al., 2011; Hillis et al., 2018), may be the most important.Whether or not recruitment of the right hemisphere (a) is a sign of “incomplete recovery” or “less effective compensation”(Heiss and Thiel, 2006),(b) occurs only as a transient phenomenon during the recovery process (Saur et al., 2006), or (c) indicates use of built-in redundancy (Turkeltaub et al., 2011; Marchina et al., 2018; Ozdemir et al., 2006) to facilitate recovery in case of an insult to the left hemisphere is still a matter of debate.
DOI: 10.1016/j.neuroimage.2011.12.057
发表时间: 2012-04-02
期刊: NEUROIMAGE
影响因子: 5.7
作者:
Fridriksson, Julius;Richardson, Jessica D.;Fillmore, Paul;Cai, Bo
通讯作者: Cai, Bo
DOI: 10.1002/ana.24983
发表时间: 2017-07
影响因子: 11.2
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DOI: 10.1093/brain/aww002
发表时间: 2016-04-01
期刊: BRAIN
影响因子: 14.5
作者:
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DOI: 10.1093/brain/awu163
发表时间: 2014-10
期刊: Brain : a journal of neurology
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DOI: 10.1093/cercor/4.4.331
发表时间: 1994-07-01
期刊: CEREBRAL CORTEX
影响因子: 3.7
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