Left hemisphere plasticity and aphasia recovery.
Left hemisphere plasticity and aphasia recovery.
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DOI：
10.1016/j.neuroimage.2011.12.057
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发表时间：
2012-04-02
期刊：
影响因子：
5.7
通讯作者：
Cai, Bo
中科院分区：
文献类型：
--
作者：
Fridriksson, Julius;Richardson, Jessica D.;Fillmore, Paul;Cai, Bo
我们小组最近的一项研究显示，在患有失语症的慢性中风患者(N=26)中，左侧大脑半球的功能变化与失范治疗结果之间存在很强的相关性。目前的研究代表了这项工作的继续，在这项工作中，我们改进了我们的方法，并增加了来自另外四名患者的数据(总样本量为30人)，以评估左半球与治疗相关的大脑变化发生在哪里。与仅仅关注正确命名的变化作为治疗结果的标志不同，目前的研究考察了左脑活动的变化与治疗后正确命名、语义性错语和音素性错语的变化之间的关系。我们还通过检验在基线(此后定义为失调症治疗开始前的时间点)采取的神经生理学措施是否可以预测治疗结果，扩展了Fridriksson的工作。我们的分析显示，在慢性失语症患者中，皮损周围区激活的变化预示着与治疗相关的正确命名的增加。这种关系最容易在左额叶观察到。在14名正常受试者的图片命名过程中，大脑皮质区域的激活变化可以预测语义性和音音性失语症数量的减少。相比之下，基线神经生理学指标和失调症治疗结果之间的关系则不那么确定。我们的发现表明，失语症患者的命名改善与行为异常治疗相关，与左侧额叶的调节有关，而命名错误的减少是由左侧后部区域介导的，这些区域通常被认为与语言处理有关。
A recent study by our group revealed a strong relationship between functional brain changes in the left hemisphere and anomia treatment outcome in chronic stroke patients (N=26) with aphasia. The current research represents a continuation of this work in which we have refined our methods and added data from four more patients (for a total sample size of 30) to assess where in the left hemisphere treatment-related brain changes occur. Unlike which only focused on changes in correct naming as a marker of treatment outcome, the current study examined the relationship between changes in left hemisphere activity and changes in correct naming, semantic paraphasias, and phonemic paraphasias following treatment. We also expanded on the work by Fridriksson by examining whether neurophysiological measures taken at baseline (defined henceforth as the time-point before the start of anomia treatment) predict treatment outcome. Our analyses revealed that changes in activation in perilesional areas predicted treatment-related increases in correct naming in individuals with chronic aphasia. This relationship was most easily observed in the left frontal lobe. Decrease in the number of semantic and phonemic paraphasias was predicted by activation change in the temporal lobe involving cortical areas that were shown to be active during picture naming in 14 normal subjects. In contrast, a far less certain relationship was found between baseline neurophysiological measures and anomia treatment outcome. Our findings suggest that improved naming associated with behavioral anomia treatment in aphasia is associated with modulation of the left frontal lobe whereas reduction in naming errors is mediated by left posterior regions that classically are thought to be involved in language processing.
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DOI：
10.1523/jneurosci.2227-10.2010
发表时间：
2010-09-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fridriksson J
通讯作者：
Fridriksson J
影响因子：
5.7
作者：
Bonakdarpour, B.;Parrish, T. B.;Thompson, C. K.
通讯作者：
Thompson, C. K.
影响因子：
3.7
作者：
Fridriksson, Julius;Bonilha, Leonardo;Rorden, Chris
通讯作者：
Rorden, Chris
影响因子：
4.8
作者：
Fridriksson, Julius;Baker, Julie M.;Moser, Dana
通讯作者：
Moser, Dana
影响因子：
3.2
作者：
Crosson, B;Moore, AB;Rothi, LJG
通讯作者：
Rothi, LJG