Extracellular vesicles in spontaneous preterm birth.
Extracellular vesicles in spontaneous preterm birth.
复制标题
自发性早产的细胞外囊泡。
DOI：
10.1111/aji.13353
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Shahin H
中科院分区：
文献类型：
--
作者：
Menon R;Shahin H
胎母沟通有助于维持妊娠，有助于足月和早产分娩。内分泌和免疫因子是报道较多的通讯介质。细胞外囊泡（EV）生物学的最新进展表明，它们是母亲和胎儿之间的主要通信通道。EVs为圆形结构，具有脂质双层膜。电动汽车通常根据其大小和生物发生方式进行分类。最常见的EVs是外泌体，大小范围为30 ~ 160 nm，形成于多泡体的腔内小泡内。微囊泡（MVs）是由质膜向外出芽形成的，体积大于100 ~ 200nm。囊泡从所有细胞中释放出来，并携带各种因子，这些因子反映了囊泡释放时细胞的生理状态。对囊泡的分析提供了起源细胞的快照。最近围产期医学的研究表明，外泌体是胎母单位之间的关键通讯体，它们可以穿越胎盘。胎儿源性外泌体在足月分娩相关条件下释放，可引起母体子宫组织分娩相关变化。在动物模型中，携带炎性货物的外泌体可导致早产，这表明它们在分娩中的功能作用。一些报道描述了足月妊娠和早产妊娠的外泌体货物之间的差异，并指出它们的生物标志物潜力可以预测高危妊娠状态。很少有关于mv及其在生殖中的功能作用的报道。在此，我们回顾ev和mv，它们的特点，功能和预测不良妊娠并发症，如早产的有效性。
Feto-maternal communication helps to maintain pregnancy and contributes to parturition at term and preterm. Endocrine and immune factor are well reported communication mediators. Recent advances in extracellular vesicle (EV) biology has introduced them as major communication channels between the mother and fetus. EVs are round structures with a lipid bilayer membrane. EVs are generally categorized based on their size and mode of biogenesis. The most commonly reported EVs are exosomes with a size range of 30 −160 nm that are formed inside the intraluminal vesicles of multivesicular body. Microvesicles (MVs) are larger than > 200nm and formed by outward budding of plasma membrane. Vesicles are released from all cells and carry various factors that reflect the physiologic state of cell at the time of their release. Analysis of vesicle provides a snapshot of origin cell. Recent studies in perinatal medicine has shown that exosomes are key communicators between feto-maternal units, and they can cross placenta. Fetal derived exosomes released under term labor associated conditions can cause parturition associated changes in maternal uterine tissues. Exosomes carrying inflammatory cargo can cause preterm birth in animal models suggesting their functional role in parturition. A few reports have profiled differences between exosome cargos from term and preterm pregnancies and indicated their biomarker potential to predict high risk pregnancy status. There are hardly any reports on MVs and their functional roles in reproduction. Herein, we review of EVs and MVs, their characteristics, function, and usefulness predicting adverse pregnancy complications such as preterm birth.
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DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
影响因子：
9.8
作者：
Ilekis JV;Tsilou E;Fisher S;Abrahams VM;Soares MJ;Cross JC;Zamudio S;Illsley NP;Myatt L;Colvis C;Costantine MM;Haas DM;Sadovsky Y;Weiner C;Rytting E;Bidwell G
通讯作者：
Bidwell G
影响因子：
9.8
作者：
Behnia, Faranak;Taylor, Brandie D.;Menon, Ramkumar
通讯作者：
Menon, Ramkumar
DOI：
10.1073/pnas.1418401112
发表时间：
2015-03-24
影响因子：
11.1
作者：
Kanada, Masamitsu;Bachmann, Michael H.;Contag, Christopher H.
通讯作者：
Contag, Christopher H.
影响因子：
7.5
作者：
Aharon, Anat;Brenner, Benjamin
通讯作者：
Brenner, Benjamin