Striatal dopamine D1-type receptor availability: no difference from control but association with cortical thickness in methamphetamine users.
Striatal dopamine D1-type receptor availability: no difference from control but association with cortical thickness in methamphetamine users.
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DOI：
10.1038/mp.2017.172
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发表时间：
2018-05
影响因子：
11
通讯作者：
London ED
中科院分区：
文献类型：
--
作者：
Okita K;Morales AM;Dean AC;Johnson MC;Lu V;Farahi J;Mandelkern MA;London ED
长期使用甲基苯丙胺对直接受影响的个人和社会造成潜在的破坏性后果。与对照组相比，甲基苯丙胺吸毒者纹状体内多巴胺D2型受体的利用率较低，但D1型受体的类似比较仅在死后标本上进行，在尾状核和壳核中，甲基苯丙胺吸毒者与对照组之间没有差异，而伏隔核中的D1型受体密度较高。当自我给予甲基苯丙胺时，多巴胺从神经元中释放出来，与纹状体中的D1型和D2型受体结合，对皮质活动产生下游影响。因此，这两种受体亚型可能与甲基苯丙胺引起的大脑皮层形态和行为改变有关。在这项研究中，21名甲基苯丙胺依赖者和23名健康对照分别参加了正电子发射断层扫描和结构磁共振成像，以评估纹状体D1型和D2型受体的可用性和皮质灰质厚度。如前所述，尽管甲基苯丙胺组的D2型受体利用率(BPND)较低，但两组在D1型BPND方面没有差异。在甲基苯丙胺组，平均皮质灰质厚度与甲基苯丙胺的累积使用和对药物的渴求呈负相关。甲基苯丙胺组纹状体D1型而非D2型BPND与皮质灰质平均厚度呈负相关，而对照组中两种多巴胺受体亚型的灰质厚度与BPND均无关联。这些结果提示纹状体D1型受体在皮质对长期使用甲基苯丙胺的适应中起作用。
Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted only on postmortem material, with no differences in methamphetamine users from controls in the caudate nucleus and putamen and higher D1 receptor density in the nucleus accumbens. Released from neurons when methamphetamine is self-administered, dopamine binds to both D1- and D2-type receptors in the striatum, with downstream effects on cortical activity. Thus, both receptor subtypes may contribute to methamphetamine-induced alterations in cortical morphology and behavior. In this study, 21 methamphetamine-dependent subjects and 23 healthy controls participated in positron emission tomography and structural magnetic resonance imaging for assessment of striatal D1- and D2-type receptor availability and cortical gray-matter thickness, respectively. Although D2-type receptor availability (BPND) was lower in the methamphetamine group, as shown previously, the groups did not differ in D1-type BPND. In the methamphetamine group, mean cortical gray-matter thickness was negatively associated with cumulative methamphetamine use and craving for the drug. Striatal D1-type but not D2-type BPND was negatively associated with global mean cortical gray-matter thickness in the methamphetamine group, but no association was found between gray-matter thickness and BPND for either dopamine-receptor subtype in the control group. These results suggest a role of striatal D1-type receptors in cortical adaptation to chronic methamphetamine use.
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影响因子：
3.7
作者：
Connolly CG;Bell RP;Foxe JJ;Garavan H
通讯作者：
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3.3
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影响因子：
5.3
作者：
Freeze, Benjamin S.;Kravitz, Alexxai V.;Kreitzer, Anatol C.
通讯作者：
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