The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells.
The capacity of the TNF family members 4-1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells.
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DOI：
10.1002/eji.200838250
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发表时间：
2008-10
影响因子：
5.4
通讯作者：
Steinberger, Peter
中科院分区：
文献类型：
--
作者：
Kober, Johanna;Leitner, Judith;Klauser, Christoph;Woitek, Ramona;Majdic, Otto;Stoeckl, Johannes;Herndler-Brandstetter, Dietmar;Grubeck-Loebenstein, Beatrix;Reipert, Birgit M.;Pickl, Winfried F.;Pfistershammer, Katharina;Steinberger, Peter
肿瘤坏死因子受体(TNFR)超家族成员与其同源配体相互作用产生的激活信号在T细胞应答中起着重要作用。肿瘤坏死因子家族的成员，即4-1BBL、OX40L、CD70、GITRL、LIGH和CD30L，已被描述为通过与T细胞结合而发挥共刺激分子的功能。使用我们最近描述的T细胞刺激细胞系统，我们进行了第一次研究，其中所有这些分子都被评估并比较了它们协同刺激人类T细胞增殖和细胞因子产生的能力。4-1BBL是我们发现的这个组中最有效的分子，它能够介导人T细胞的持续激活和增殖。OX40L和CD70对T细胞的增殖也有很强的诱导作用，而人GITRL的共刺激能力明显降低。重要的是，CD30L和光始终不能对人类T细胞起共刺激作用，因此我们认为这些分子可能在功能上不同于该家族的共刺激成员。
Activating signals generated by members of the tumour necrosis factor receptor (TNFR) superfamily upon interaction with their cognate ligands play important roles in T cell responses. Members of the tumour necrosis factor (TNF) family namely 4-1BBL, OX40L, CD70, GITRL, LIGHT and CD30L have been described to function as costimulatory molecules by binding such receptors on T cells. Using our recently described system of T cell stimulator cells we have performed the first study where all these molecules have been assessed and compared regarding their capacity to costimulate proliferation and cytokine production of human T cells. 4-1BBL, which we found to be the most potent molecule in this group was able to mediate sustained activation and proliferation of human T cells. OX40L and CD70 were also strong inducers of T cell proliferation, whereas the costimulatory capacity of human GITRL was significantly lower. Importantly CD30L and LIGHT consistently failed to act costimulatory on human T cells, and we therefore suggest that these molecules might be functionally distinct from the costimulatory members of this family.
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影响因子：
4.4
作者：
Hamann, D;Kostense, S;van Lier, RAW
通讯作者：
van Lier, RAW
影响因子：
15.3
作者：
Shuford, WW;Klussman, K;Tritchler, DD;Loo, DT;Chalupny, J;Siadak, AW;Brown, TJ;Emswiler, J;Raecho, H;Larsen, CP;Pearson, TC;Ledbetter, JA;Aruffo, A;Mittler, RS
通讯作者：
Mittler, RS
影响因子：
4.4
作者：
Gramaglia, I;Jember, A;Croft, M
通讯作者：
Croft, M
DOI：
10.1016/0167-5699(92)90157-3
发表时间：
1992-06-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
HANNET, I;ERKELLERYUKSEL, F;DEBRUYERE, M
通讯作者：
DEBRUYERE, M
影响因子：
4.4
作者：
Bansal-Pakala, P;Halteman, BS;Croft, M
通讯作者：
Croft, M