Yin and Yang of disease genes and death genes between reciprocally scale-free biological networks.
Yin and Yang of disease genes and death genes between reciprocally scale-free biological networks.
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DOI：
10.1093/nar/gkt683
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发表时间：
2013-11
影响因子：
14.9
通讯作者：
Kim JH
中科院分区：
文献类型：
--
作者：
Han HW;Ohn JH;Moon J;Kim JH
Biological networks often show a scale-free topology with node degree following a power-law distribution. Lethal genes tend to form functional hubs, whereas non-lethal disease genes are located at the periphery. Uni-dimensional analyses, however, are flawed. We created and investigated two distinct scale-free networks; a protein–protein interaction (PPI) and a perturbation sensitivity network (PSN). The hubs of both networks exhibit a low molecular evolutionary rate (P < 8 × 10−12, P < 2 × 10−4) and a high codon adaptation index (P < 2 × 10−16, P < 2 × 10−8), indicating that both hubs have been shaped under high evolutionary selective pressure. Moreover, the topologies of PPI and PSN are inversely proportional: hubs of PPI tend to be located at the periphery of PSN and vice versa. PPI hubs are highly enriched with lethal genes but not with disease genes, whereas PSN hubs are highly enriched with disease genes and drug targets but not with lethal genes. PPI hub genes are enriched with essential cellular processes, but PSN hub genes are enriched with environmental interaction processes, having more TATA boxes and transcription factor binding sites. It is concluded that biological systems may balance internal growth signaling and external stress signaling by unifying the two opposite scale-free networks that are seemingly opposite to each other but work in concert between death and disease.
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DOI：
10.1136/amiajnl-2012-001519
发表时间：
2013-07
期刊：
Journal of the American Medical Informatics Association : JAMIA
影响因子：
--
作者：
Lee Y;Li H;Li J;Rebman E;Achour I;Regan KE;Gamazon ER;Chen JL;Yang XH;Cox NJ;Lussier YA
通讯作者：
Lussier YA
影响因子：
56.9
作者：
Landry, Christian R.;Lemos, Bernardo;Hartl, Daniel L.
通讯作者：
Hartl, Daniel L.
影响因子：
64.8
作者：
Jeong, H;Mason, SP;Oltvai, ZN
通讯作者：
Oltvai, ZN
影响因子：
5.8
作者：
Ohn, Jung Hun;Kim, Jihun;Kim, Ju Han
通讯作者：
Kim, Ju Han
影响因子：
3.4
作者：
Wuchty, S;Almaas, E
通讯作者：
Almaas, E