MicroRNA-Gene Interactions Impacted by Toxic Metal(oid)s during EMT and Carcinogenesis.
MicroRNA-Gene Interactions Impacted by Toxic Metal(oid)s during EMT and Carcinogenesis.
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作者：
上皮 - 层状的转变的特征是细胞粘合剂的丧失和该现象的增加金属（LIE）是已知的人类致癌物，可以调节microRNA表达，从而导致上皮 - 层状过渡和癌变还提出了最初的研究发现，这些发现进一步表征了镉诱导的上皮 - 间质转变的机制。
慢性环境暴露于有毒金属（LOID）显着有助于人类癌症的发展和进展。 EMT的早期癌作用受到许多基因和microRNA（miRNA）的调节，可控制细胞存活，死亡和/或分化。最近的机械研究表明，有毒金属（Lie）改变了涉及EMT的基因的表达在这项迷你综述中，miRNA可以作为癌症患者的治疗靶标。突出显示了暴露于有毒金属（LIE）（包括砷，镉，镍和铬）后EMT扰动的化学 - miRNA -Gene相互作用。
Epithelial–mesenchymal transition is characterized by the loss of cellular adhesion and an increase in cellular motility. This phenomenon is mediated through several oncogenic signaling pathways. MicroRNAs are epigenetic regulators that can modulate both oncogenic signaling pathways and the expression of cellular adhesion proteins. Many toxic metal(loid)s are known human carcinogens and can modulate microRNA expression, resulting in epithelial–mesenchymal transition and carcinogenesis. This mini review summarizes the microRNA–gene interactions of toxic metal(loid)s in epithelial–mesenchymal transition and carcinogenesis. By doing so, we hope to highlight certain miRNAs that can be potential therapeutic targets in treating metal carcinogenesis. We also present original research findings that further characterize the mechanisms of cadmium-induced epithelial–mesenchymal transition. Chronic environmental exposure to toxic metal(loid)s significantly contributes to human cancer development and progression. It is estimated that approximately 90% of cancer deaths are a result of metastasis of malignant cells, which is initiated by epithelial–mesenchymal transition (EMT) during early carcinogenesis. EMT is regulated by many families of genes and microRNAs (miRNAs) that control signaling pathways for cell survival, death, and/or differentiation. Recent mechanistic studies have shown that toxic metal(loid)s alter the expression of miRNAs responsible for regulating the expression of genes involved in EMT. Altered miRNA expressions have the potential to be biomarkers for predicting survival and responses to treatment in cancers. Significantly, miRNAs can be developed as therapeutic targets for cancer patients in the clinic. In this mini review, we summarize key findings from recent studies that highlight chemical–miRNA–gene interactions leading to the perturbation of EMT after exposure to toxic metal(loid)s including arsenic, cadmium, nickel, and chromium.
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DOI：
10.1083/jcb.153.5.1049
发表时间：
2001-05-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gottardi CJ;Wong E;Gumbiner BM
通讯作者：
Gumbiner BM
DOI：
10.1073/pnas.1701703114
发表时间：
2017-07-18
影响因子：
11.1
作者：
Hart, Kevin C.;Tan, Jiongyi;Gloerich, Martijn
通讯作者：
Gloerich, Martijn
影响因子：
4.3
作者：
Hu, Liyan;Liu, Xin;Dai, Wei
通讯作者：
Dai, Wei
影响因子：
3.6
作者：
Chen QY;Costa M
通讯作者：
Costa M
影响因子：
4.6
作者：
Campbell, Kyra;Casanova, Jordi
通讯作者：
Casanova, Jordi