Proteins with an Euonymus lectin-like domain are ubiquitous in Embryophyta.
Proteins with an Euonymus lectin-like domain are ubiquitous in Embryophyta.
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DOI：
10.1186/1471-2229-9-136
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发表时间：
2009-11-23
影响因子：
5.3
通讯作者：
Van Damme EJ
中科院分区：
文献类型：
--
作者：
Fouquaert E;Peumans WJ;Vandekerckhove TT;Ongenaert M;Van Damme EJ
对卫矛凝集素的克隆发现了一个新的结构域，该结构域也出现在一些胁迫诱导的植物蛋白中。利用公开的基因组和转录组数据库，对卫矛凝集素（EUL）结构域蛋白的分布和多样性进行了详细分析。综合计算机分析表明，最近发现的欧洲卫矛凝集素结构域代表了一个新的假定的碳水化合物结合蛋白家族的保守结构单元，该家族将进一步被称为卫矛凝集素（EUL）家族。EUL结构域在植物中广泛存在。对检索序列的分析表明，一些序列由一个与不相关的n端结构域相连的单一EUL结构域组成，而另一些序列则由两个串联排列的EUL结构域组成。提出了一种基于整体域结构的凝集素分类体系。讨论了具有EUL结构域的序列之间的演化关系。EUL家族的鉴定为陆生植物中存在高度保守的植物特异域提供了第一个证据。EUL结构域的广泛分布与在植物中发现的大多数其他凝集素结构域的更有限甚至狭窄的分布形成鲜明对比。EUL结构域的明显无所不在表明该凝集素结构域在植物中的普遍作用。虽然有明确的证据表明，一些EUL结构域具有碳水化合物结合活性，但需要进一步的研究来证实EUL家族不同成员的碳水化合物结合特性。
Cloning of the Euonymus lectin led to the discovery of a novel domain that also occurs in some stress-induced plant proteins. The distribution and the diversity of proteins with an Euonymus lectin (EUL) domain were investigated using detailed analysis of sequences in publicly accessible genome and transcriptome databases. Comprehensive in silico analyses indicate that the recently identified Euonymus europaeus lectin domain represents a conserved structural unit of a novel family of putative carbohydrate-binding proteins, which will further be referred to as the Euonymus lectin (EUL) family. The EUL domain is widespread among plants. Analysis of retrieved sequences revealed that some sequences consist of a single EUL domain linked to an unrelated N-terminal domain whereas others comprise two in tandem arrayed EUL domains. A new classification system for these lectins is proposed based on the overall domain architecture. Evolutionary relationships among the sequences with EUL domains are discussed. The identification of the EUL family provides the first evidence for the occurrence in terrestrial plants of a highly conserved plant specific domain. The widespread distribution of the EUL domain strikingly contrasts the more limited or even narrow distribution of most other lectin domains found in plants. The apparent omnipresence of the EUL domain is indicative for a universal role of this lectin domain in plants. Although there is unambiguous evidence that several EUL domains possess carbohydrate-binding activity further research is required to corroborate the carbohydrate-binding properties of different members of the EUL family.
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影响因子：
7.4
作者：
MOONS, A;BAUW, G;Van Der Straeten, D
通讯作者：
Van Der Straeten, D
影响因子：
11.6
作者：
Leonhardt, N;Kwak, JM;Schroeder, JI
通讯作者：
Schroeder, JI
影响因子：
3
作者：
Van Damme, Els J M;Lannoo, Nausicaa;Peumans, Willy J
通讯作者：
Peumans, Willy J
树突镜：大型系统发育树的互动观众。
影响因子：
3
作者：
Huson, Daniel H.;Richter, Daniel C.;Rausch, Christian;Dezulian, Tobias;Franz, Markus;Rupp, Regula
通讯作者：
Rupp, Regula
影响因子：
3.4
作者：
Carpentier, Sebastien C.;Witters, Erwin;Panis, Bart
通讯作者：
Panis, Bart