Advances and challenges in intravital imaging of craniofacial and dental progenitor cells.
Advances and challenges in intravital imaging of craniofacial and dental progenitor cells.
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DOI：
10.1002/dvg.23498
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发表时间：
2022-09
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影响因子：
--
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中科院分区：
文献类型：
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颅面骨和阑尾骨的动态平衡分别由成骨细胞和破骨细胞在骨形成和骨吸收之间的平衡来调节。尽管骨生物学的多种成像技术得到了发展，但在研究活体动物牙齿和颅面骨中稀有干细胞/祖细胞的空间/解剖位置及其分子调控方面仍存在技术挑战和局限性。颅面和牙科器械活体成像技术的最新进展可以为实时了解骨干/祖细胞的动态和体内功能提供新的见解。本文综述了目前无创活体成像技术的发明和应用，以及其在体内颅面和牙器官干细胞/祖细胞分析中的实际应用和局限性。此外，我们还探讨了活体显微技术在牙科领域的潜在应用。颅面骨和牙器械中骨干/祖细胞实时活体成像的最新进展和局限性
Craniofacial and appendicular bone homeostasis is dynamically regulated by a balance between bone formation and resorption by osteoblasts and osteoclasts, respectively. Despite the developments in multiple imaging techniques in bone biology, there are still technical challenges and limitations in the investigation of spatial/anatomical location of rare stem/progenitor cells and their molecular regulation in tooth and craniofacial bones of living animals. Recent advances in live animal imaging techniques for the craniofacial and dental apparatus can provide new insights in real time into bone stem/progenitor cell dynamics and function in vivo. Here we review the current inventions and applications of the non-invasive intravital imaging technique and its practical uses and limitations in the analysis of stem/progenitor cells in craniofacial and dental apparatus in vivo. Furthermore, we also explore the potential applications of intravital microscopy in the dental field. Recent progress and limitations in real-time intravital imaging of skeletal stem/progenitor cells residing in craniofacial bones and the dental apparatus
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影响因子：
16.6
作者：
Akalestou E;Suba K;Lopez-Noriega L;Georgiadou E;Chabosseau P;Gallie A;Wretlind A;Legido-Quigley C;Leclerc I;Salem V;Rutter GA
通讯作者：
Rutter GA
影响因子：
11.2
作者：
Brighton HE;Angus SP;Bo T;Roques J;Tagliatela AC;Darr DB;Karagoz K;Sciaky N;Gatza ML;Sharpless NE;Johnson GL;Bear JE
通讯作者：
Bear JE
影响因子：
--
作者：
Fujii, Akira;Matsumoto, Hiroko;Jiang, Gui-Zhen
通讯作者：
Jiang, Gui-Zhen
影响因子：
8
作者：
Gyarmati G;Shroff UN;Izuhara A;Hou X;Da Sacco S;Sedrakyan S;Lemley KV;Amann K;Perin L;Peti-Peterdi J
通讯作者：
Peti-Peterdi J
影响因子：
16.6
作者：
Honkura N;Richards M;Laviña B;Sáinz-Jaspeado M;Betsholtz C;Claesson-Welsh L
通讯作者：
Claesson-Welsh L