Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia.
Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia.
复制标题
DOI：
10.1016/j.bbi.2013.01.087
复制
发表时间：
2013-08
影响因子：
15.1
通讯作者：
Leonard, Sherry
中科院分区：
文献类型：
--
作者：
Sinkus, Melissa L.;Adams, Catherine E.;Logel, Judith;Freedman, Robert;Leonard, Sherry
精神分裂症是一种常见的精神疾病，具有很大的遗传成分。三项全基因组关联研究表明，染色体 6p21.3-22.1 上的主要组织相容性复合体基因区域与精神分裂症有关。此外，在精神分裂症中常见的尼古丁会影响中枢神经系统免疫基因的表达。在 89 名受试者死后海马体中测量了 6p21.3-22.1 区域基因的信使 RNA 水平。比较了精神分裂症诊断、吸烟和全身炎症性疾病的影响。利用原位杂交探索了 I 类主要组织相容性复合体基因 HLA-A 的细胞特异性表达模式。精神分裂症受试者中有五个基因的表达发生了改变。精神分裂症非吸烟者中 I 类主要组织相容性复合体抗原 HLA-B 的信使 RNA 水平升高，而吸烟者的水平与对照组没有区别。 β2 微球蛋白、HLA-A 和 Notch4 的表达模式均与对照组的炎症性疾病相关，但在精神分裂症患者中则不然。精神分裂症也与嗜丁蛋白 2A2 表达增加有关。 HLA-A 在海马 CA1-CA4 区域的齿状回、门和锥体层的谷氨酸能和 GABA 能神经元中表达，但在星形胶质细胞中不表达。总之，6 号染色体主要组织相容性复合体区域中可能在突触发育中发挥作用的基因表达在精神分裂症中发生了改变。精神分裂症的诊断与炎症性疾病和吸烟之间也存在显着的相互作用。
Schizophrenia is a common mental illness with a large genetic component. Three genome-wide association studies have implicated the major histocompatibility complex gene region on chromosome 6p21.3-22.1 in schizophrenia. In addition, nicotine, which is commonly abused in schizophrenia, affects the expression of central nervous system immune genes. Messenger RNA levels for genes in the 6p21.3-22.1 region were measured in human postmortem hippocampus of 89 subjects. The effects of schizophrenia diagnosis, smoking and systemic inflammatory illness were compared. Cell-specific expression patterns for the class I major histocompatibility complex gene HLA-A were explored utilizing in situ hybridization. Expression of five genes was altered in schizophrenic subjects. Messenger RNA levels for the class I major histocompatibility complex antigen HLA-B were increased in schizophrenic nonsmokers, while levels for smokers were indistinguishable from those of controls. β2 microglobulin, HLA-A and Notch4 were all expressed in a pattern where inflammatory illness was associated with increased expression in controls but not in subjects with schizophrenia. Schizophrenia was also associated with increased expression of Butyrophilin 2A2. HLA-A was expressed in glutamatergic and GABAergic neurons in the dentate gyrus, hilus, and the stratum pyramidale of the CA1-CA4 regions of the hippocampus, but not in astrocytes. In conclusion, the expression of genes from the major histocompatibility complex region of chromosome 6 with likely roles in synaptic development is altered in schizophrenia. There were also significant interactions between schizophrenia diagnosis and both inflammatory illness and smoking.
登录
查看更多内容
影响因子：
56.9
作者：
Huh, GS;Boulanger, LM;Shatz, CJ
通讯作者：
Shatz, CJ
影响因子：
4.5
作者：
Khandaker, Golam M.;Zimbron, Jorge;Dalman, Christina;Lewis, Glyn;Jones, Peter B.
通讯作者：
Jones, Peter B.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
17.7
作者：
Brown, AS;Hooton, J;Susser, ES
通讯作者：
Susser, ES
影响因子：
17.7
作者：
Freedman, Robert;Olincy, Ann;Kem, William R.
通讯作者：
Kem, William R.