Exploring disease interrelationships in patients with lymphatic disorders: A single center retrospective experience.
Exploring disease interrelationships in patients with lymphatic disorders: A single center retrospective experience.
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DOI：
10.1002/ctm2.760
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发表时间：
2022-04
影响因子：
10.6
通讯作者：
Nicolls, Mark R.
中科院分区：
文献类型：
--
作者：
Rockson, Stanley G.;Zhou, Xin;Zhao, Lan;Hosseini, Davood K.;Jiang, Xinguo;Sweatt, Andrew J.;Kim, Dongeon;Tian, Wen;Snyder, Michael P.;Nicolls, Mark R.
关键词：
淋巴对循环的贡献在调节流体稳态、免疫细胞运输/活化和脂质代谢中至关重要。与血管系统相比，在健康和疾病方面，血管造影的影响一直未得到充分重视，这可能是由于解剖结构和功能不太清楚。新出现的数据表明，淋巴功能障碍可能在广泛器官系统各种疾病的发生和发展中发挥关键作用。了解淋巴功能障碍和非淋巴发病率之间的临床关联为未来的研究提供了有价值的证据，并可能促进新的生物标志物和治疗方法的发现。我们回顾性分析了724例转诊至斯坦福大学淋巴和静脉疾病中心的患者的电子病历。确定淋巴诊断的患者被分为继发性淋巴水肿、脂肪水肿或原发性淋巴血管疾病组。将未发现淋巴疾病的个体作为非淋巴对照。列举了共病的患病率。通过Jaccard相似性检验验证的成对共现模式分析用于研究疾病间的相互关系。共同分析强调了继发性淋巴水肿的存在与损害淋巴系统的疾病之间的预期关系。心血管疾病在所有淋巴亚组中均很常见。此外，与对照人群相比，在所有三个淋巴类别中观察到疾病-疾病相互关系的统计学显著性改变。淋巴疾病的存在或不存在显著影响研究队列中疾病的相互关系。作为一种生理基质，淋巴循环可能是疾病发病机制中未被充分认识的参与者。这些关系值得进一步的前瞻性审查和研究。临床评估来自斯坦福大学淋巴和静脉疾病中心的患者是否存在淋巴疾病。将所有相关共病ICD-10诊断制表，以进行统计分析。该研究揭示了淋巴功能障碍的存在改变了疾病的相互关系。未来的前瞻性研究可能为疾病的发病机制和靶向分子治疗提供新的概念。
The lymphatic contribution to the circulation is of paramount importance in regulating fluid homeostasis, immune cell trafficking/activation and lipid metabolism. In comparison to the blood vasculature, the impact of the lymphatics has been underappreciated, both in health and disease, likely due to a less well‐delineated anatomy and function. Emerging data suggest that lymphatic dysfunction can be pivotal in the initiation and development of a variety of diseases across broad organ systems. Understanding the clinical associations between lymphatic dysfunction and non‐lymphatic morbidity provides valuable evidence for future investigations and may foster the discovery of novel biomarkers and therapies. We retrospectively analysed the electronic medical records of 724 patients referred to the Stanford Center for Lymphatic and Venous Disorders. Patients with an established lymphatic diagnosis were assigned to groups of secondary lymphoedema, lipoedema or primary lymphovascular disease. Individuals found to have no lymphatic disorder were served as the non‐lymphatic controls. The prevalence of comorbid conditions was enumerated. Pairwise co‐occurrence pattern analyses, validated by Jaccard similarity tests, was utilised to investigate disease–disease interrelationships. Comorbidity analyses underscored the expected relationship between the presence of secondary lymphoedema and those diseases that damage the lymphatics. Cardiovascular conditions were common in all lymphatic subgroups. Additionally, statistically significant alteration of disease–disease interrelationships was noted in all three lymphatic categories when compared to the control population. The presence or absence of a lymphatic disease significantly influences disease interrelationships in the study cohorts. As a physiologic substrate, the lymphatic circulation may be an underappreciated participant in disease pathogenesis. These relationships warrant further, prospective scrutiny and study. Patients from the Stanford Center for Lymphatic and Venous Disorders were clinically assessed for the presence/absence of lymphatic disorders. All relevant comorbid ICD‐10 diagnoses were tabulated to permit statistical analysis. The study disclosed that the presence of lymphatic dysfunction alters disease interrelationships. Future prospective study may provide novel concepts regarding disease pathogenesis and targeted molecular therapeutics.
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DOI：
10.1098/rsif.2018.0248
发表时间：
2018-10-31
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Chami GF;Kabatereine NB;Tukahebwa EM;Dunne DW
通讯作者：
Dunne DW
影响因子：
2.8
作者：
BILANCINI, S;LUCCHI, M;ELEUTERI, P
通讯作者：
ELEUTERI, P
DOI：
10.1016/j.remn.2018.06.008
发表时间：
2018-11-01
影响因子：
1.2
作者：
Forner-Cordero, I.;Olivan-Sasot, P.;Munoz-Langa, J.
通讯作者：
Munoz-Langa, J.
影响因子：
3.1
作者：
Lohrmann, Christian;Foeldi, Etelka;Langer, Mathias
通讯作者：
Langer, Mathias
影响因子：
3
作者：
Chung, Neo Christopher;Miasojedow, Blazej;Gambin, Anna
通讯作者：
Gambin, Anna