The prefrontal cortex and oculomotor delayed response: a reconsideration of the "mnemonic scotoma".
The prefrontal cortex and oculomotor delayed response: a reconsideration of the "mnemonic scotoma".
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DOI：
10.1162/jocn_a_00171
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发表时间：
2012-03
影响因子：
3.2
通讯作者：
Postle BR
中科院分区：
文献类型：
--
作者：
Tsujimoto S;Postle BR
“记忆暗点”的概念是由单侧前额叶皮层（PFC）损伤产生的工作记忆障碍的空间限制区域，它是PFC对短期信息保留至关重要的观点的核心。然而，这里提出了以前未发表的数据，为这种赤字模式提供了另一种非助记性解释。在他们的研究中，K. Wajima和T. Sawaguchi在两只猴子执行动眼性延迟反应任务时，将GABAA拮抗剂双丘碱（bicuculline methiode）单侧应用于它们的PFC。与先前的研究一致，当提示位置落在受输液影响的视野区域时，初始记忆引导扫视的误差明显更高。这些错误的扫视倾向于选择一个在试验中没有提示的替代目标位置（从可能的16个位置中）。然而，通过扩展分析窗口，可以观察到第二次“纠正性”眼跳往往获得了在该试验中提示的位置。对错误的最初扫视的进一步分析表明，它们往往被指向与前一次试验有关的位置。因此，缺陷并不是“忘记”提示位置。相反，它是在当前和以前相关的地点之间进行选择。这些发现表明需要重新考虑助记暗点的概念，这反过来又要求重新考虑PFC中持续神经元活动的功能解释。
The concept of the “mnemonic scotoma,” a spatially circumscribed region of working memory impairment produced by unilateral lesions of the prefrontal cortex (PFC), is central to the view that the PFC is critical for the short-term retention of information. Presented here, however, are previously unpublished data that offer an alternative, nonmnemonic interpretation of this pattern of deficit. In their study, K. Wajima and T. Sawaguchi applied the GABAA antagonist bicuculline methiodide unilaterally to the PFC of two monkeys while they performed an oculomotor delayed-response task. Consistent with previous studies, errors for the initial memory-guided saccade were markedly higher when the cued location fell into the region of the visual field affected by the infusion. These erroneous saccades tended to select an alternative target location (out of a possible 16) that had not been cued on that trial. By extending the analysis window, however, it was observed that the second, “corrective” saccade often acquired the location that had been cued on that trial. Further analysis of the erroneous initial saccades indicated that they tended to be directed to a location that had been relevant on the previous trial. Thus, the deficit was not one of “forgetting” the cued location. Rather, it was one of selecting between currently and previously relevant locations. These findings suggest a need for a reconsideration of the concept of the mnemonic scotoma, which in turn invites a reconsideration of functional interpretations of sustained neuronal activity in the PFC.
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影响因子：
16.2
作者：
Histed, Mark H.;Pasupathy, Anitha;Miller, Earl K.
通讯作者：
Miller, Earl K.
DOI：
10.1523/jneurosci.5373-10.2011
发表时间：
2011-03-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Genovesio A;Tsujimoto S;Wise SP
通讯作者：
Wise SP
影响因子：
4.4
作者：
Elvevag, Brita;Maylor, Elizabeth A.;Gilbert, Abigail L.
通讯作者：
Gilbert, Abigail L.
影响因子：
56.9
作者：
FUSTER, JM;ALEXANDER, GE
通讯作者：
ALEXANDER, GE
影响因子：
2.9
作者：
Curtis, Clayton E.;D'Esposito, Mark
通讯作者：
D'Esposito, Mark