Natural history of β-cell adaptation and failure in type 2 diabetes.
Natural history of β-cell adaptation and failure in type 2 diabetes.
复制标题
DOI：
10.1016/j.mam.2014.12.002
复制
发表时间：
2015-04
影响因子：
10.6
通讯作者：
Bernal-Mizrachi, Ernesto
中科院分区：
文献类型：
--
作者：
Alejandro, Emilyn U.;Gregg, Brigid;Blandino-Rosano, Manuel;Cras-Meneur, Corentin;Bernal-Mizrachi, Ernesto
关键词：
2型糖尿病（T2D）是一种复杂的疾病，其特征是在胰岛素抵抗的情况下β细胞衰竭。目前的证据表明，遗传易感性和环境因素会损害β细胞对胰岛素抵抗的反应能力，并最终导致其失败。然而，遗传学研究表明，已知的变异占T2D总体估计风险的不到10%，这表明其他未识别的因素有助于这种疾病的易感性。在这篇综述中，我们将讨论不同的阶段，有助于β细胞衰竭的发展，在T2D。我们将这一过程的自然史分为三个主要阶段：易感性、β细胞适应和β细胞衰竭，并概述了所涉及的分子机制。对机制的进一步研究将揭示β细胞衰竭的关键调节剂，从而确定可能的新治疗靶点和潜在干预措施，以防止β细胞衰竭。
Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the setting of insulin resistance. The current evidence suggests that genetic predisposition, and environmental factors can impair the capacity of the β-cells to respond to insulin resistance and ultimately lead to their failure. However, genetic studies have demonstrated that known variants account for less than 10% of the overall estimated T2D risk, suggesting that additional unidentified factors contribute to susceptibility of this disease. In this review, we will discuss the different stages that contribute to the development of β-cell failure in T2D. We divide the natural history of this process in three major stages: susceptibility, β-cell adaptation and β-cell failure and provide an overview of the molecular mechanisms involved. Further research into mechanisms will reveal key modulators of β-cell failure and thus identify possible novel therapeutic targets and potential interventions to protect against β-cell failure.
登录
查看更多内容
影响因子：
16.6
作者：
Back SH;Kaufman RJ
通讯作者：
Kaufman RJ
影响因子：
4.8
作者：
Beith, Jennifer L.;Alejandro, Emilyn U.;Johnson, James D.
通讯作者：
Johnson, James D.
影响因子：
64.8
作者：
Apelqvist, Å;Li, H;Edlund, H
通讯作者：
Edlund, H
影响因子：
8.2
作者：
Butler, A. E.;Cao-Minh, L.;Galasso, R.;Rizza, R. A.;Corradin, A.;Cobelli, C.;Butler, P. C.
通讯作者：
Butler, P. C.
影响因子：
4.8
作者：
Boeni-Schnetzler, Marianne;Boller, Simone;Donath, Marc Y.
通讯作者：
Donath, Marc Y.