Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum.
Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum.
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DOI：
10.1186/s12936-021-03799-8
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发表时间：
2021-06-12
期刊：
影响因子：
3
通讯作者：
Drovetski SV
中科院分区：
文献类型：
--
作者：
Hellgren O;Kelbskopf V;Ellis VA;Ciloglu A;Duc M;Huang X;Lopes RJ;Mata VA;Aghayan SA;Inci A;Drovetski SV
虽然鸟类疟原虫物种在地球仪上广泛而常见，但关于其种群遗传变异程度的数据有限。在这里，假设鸟类血液寄生虫残留疟原虫表现出非常低的遗传多样性在其西部古北传播区（从摩洛哥到瑞典在北部和外高加索在东部）进行了测试。通过对来自36种宿主的75种不同的残余疟原虫感染中的快速进化裂殖子表面蛋白1（MSP 1）基因的一部分（块14）进行测序，研究了残余疟原虫的遗传多样性。此外，对代表共同区块14等位基因的全长MSP 1序列进行测序，以研究是否可以在区块14之外发现额外的变异。大多数（75例中的72例）测序感染共享相同的MSP 1等位基因。这种常见的等位基因以前被发现是在欧洲传播的显性等位基因。这些结果证实了来自有限数据集的早期发现，即全球传播的疟疾寄生虫P. relictum在其西部古北传播区表现出非常低的遗传多样性。这可能是最近的引入事件或选择性扫描的结果。
Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14. The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe. The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.
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