Plasmodium vivax populations revisited: mitochondrial genomes of temperate strains in Asia suggest ancient population expansion.
Plasmodium vivax populations revisited: mitochondrial genomes of temperate strains in Asia suggest ancient population expansion.
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DOI：
10.1186/1471-2148-12-22
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发表时间：
2012-02-17
影响因子：
3.4
通讯作者：
Cui L
中科院分区：
文献类型：
--
作者：
Miao M;Yang Z;Patch H;Huang Y;Escalante AA;Cui L
间日疟原虫是非洲以外分布最广的人类疟疾寄生虫，其范围延伸到温带地区。以前的研究提供了间日疟种群分化的证据，但温带间日疟寄生虫在这些分析中没有得到很好的代表。在这里，我们通过使用完整的线粒体（mt）基因组序列来阐明东亚和东南亚温带地区间日疟原虫广泛的遗传多样性和种群结构，从而解决了这一缺陷。从中国、缅甸和韩国的99个临床样本的全序列中，从26个多态位点中共鉴定出30种不同的单倍型。东亚和东南亚不同的寄生虫种群之间的显着分化，除了从韩国和中国南方的人口之间的比较。单倍型模式和结构多样性分析表明，东亚地区存在两个不同的群体，分别与东南亚群体和缅甸群体有亲缘关系。使用中性检验和错配分布分析对间日疟原虫的人口统计学历史进行了研究，揭示了整个间日疟原虫范围和缅甸人口的人口扩张事件。贝叶斯天际线分析进一步支持了古代间日疟原虫种群扩张的发生。本研究为间日疟原虫种群结构和进化提供了新的认识，特别是在亚洲温带/暖温带流行区。结果表明，中国和韩国温带地区的间日疟原虫种群与其他种群存在差异。多项分析证实了这种寄生虫的古代种群扩张。间日疟原虫种群广泛的遗传多样性与寄生虫的表型可塑性一致，这对疟疾控制具有意义。
Plasmodium vivax is the most widely distributed human malaria parasite outside of Africa, and its range extends well into the temperate zones. Previous studies provided evidence for vivax population differentiation, but temperate vivax parasites were not well represented in these analyses. Here we address this deficit by using complete mitochondrial (mt) genome sequences to elucidate the broad genetic diversity and population structure of P. vivax from temperate regions in East and Southeast Asia. From the complete mtDNA sequences of 99 clinical samples collected in China, Myanmar and Korea, a total of 30 different haplotypes were identified from 26 polymorphic sites. Significant differentiation between different East and Southeast Asian parasite populations was observed except for the comparison between populations from Korea and southern China. Haplotype patterns and structure diversity analysis showed coexistence of two different groups in East Asia, which were genetically related to the Southeast Asian population and Myanmar population, respectively. The demographic history of P. vivax, examined using neutrality tests and mismatch distribution analyses, revealed population expansion events across the entire P. vivax range and the Myanmar population. Bayesian skyline analysis further supported the occurrence of ancient P. vivax population expansion. This study provided further resolution of the population structure and evolution of P. vivax, especially in temperate/warm-temperate endemic areas of Asia. The results revealed divergence of the P. vivax populations in temperate regions of China and Korea from other populations. Multiple analyses confirmed ancient population expansion of this parasite. The extensive genetic diversity of the P. vivax populations is consistent with phenotypic plasticity of the parasites, which has implications for malaria control.
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影响因子：
10.7
作者：
Gunasekera, Anusha M.;Wickramarachchi, Thilan;Wirth, Dyann F.
通讯作者：
Wirth, Dyann F.
影响因子：
10.7
作者：
Jongwutiwes, S;Putaporntip, C;Hughes, AL
通讯作者：
Hughes, AL
影响因子：
56.9
作者：
Joy, DA;Feng, XR;Su, XZ
通讯作者：
Su, XZ
影响因子：
4.9
作者：
Clement, M;Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
3.7
作者：
Culleton R;Coban C;Zeyrek FY;Cravo P;Kaneko A;Randrianarivelojosia M;Andrianaranjaka V;Kano S;Farnert A;Arez AP;Sharp PM;Carter R;Tanabe K
通讯作者：
Tanabe K