Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021.
Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021.
复制标题
DOI：
10.1093/cid/ciac100
复制
发表时间：
2022-09-30
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
2020 年和 2021 年第一季度，全球侵袭性肺炎球菌疾病 (IPD) 的发病率有所下降，与此同时，旨在阻止 SARS-CoV-2 传播的非药物干预措施 (NPI) 也有所下降。 2021年，这些NPI策略的严格程度有所不同。我们调查了 2020-2021 年德国 IPD 病例数的年龄和血清型特异性变化。截至 2021 年 11 月 30 日的 IPD 病例按年龄组、血清型或地理位置进行分层。将 2020-2021 年 IPD 监测数据与 (1) 2015-2019 年 IPD 监测数据、(2) 2020 年和 2021 年流动性数据以及 (3) 2020 年和 2021 年 NPI 严格性数据进行比较。2021 年 4 月，0-4 岁儿童 IPD 发生率开始回到基线，到 2021 年 6 月超过基线（较基线增加 9%） 2015-2019 年的月平均值）。从 2021 年 7 月开始，5-14 岁儿童和 15-34 岁或 ≥80 岁成人的 IPD 病例有所增加，超过基线值，并且从 2021 年春季开始也有所增加。尽管 2020 年和 2021 年总体病例数较低，但疫苗血清型 IPD 的年龄分布和比例仍与往年相当。与前 5 年相比，IPD 发病率的百分比变化与活动能力的变化和NPI 严格性。继 2020 年与 2019 年冠状病毒病大流行相关的 NPI 发生急剧下降之后，德国的 IPD 水平于 2021 年春季和夏季开始恢复并超过季节性水平。 2020 年至 2021 年期间，疫苗血清型的比例基本保持一致。德国侵袭性肺炎球菌病继 2020 年大幅下降（与第一波 SARS-CoV-2 大流行同时发生）后，于 2021 年中期恢复到或超过基线水平。这种重新出现与流动性的增加和非药物干预措施的严格性降低有关。
The incidence of invasive pneumococcal disease (IPD) decreased worldwide in 2020 and the first quarter of 2021, concurrent with nonpharmaceutical interventions (NPIs) intended to stymie transmission of SARS-CoV-2. In 2021, the stringency of these NPI strategies has varied. We investigated age- and serotype-specific variations in IPD case counts in Germany in 2020–2021. IPD cases through 30 November 2021 were stratified by age group, serotype, or geographic location. IPD surveillance data in 2020–2021 were compared with (1) IPD surveillance data from 2015–2019, (2) mobility data during 2020 and 2021, and (3) NPI stringency data in 2020 and 2021. IPD incidence began to return toward baseline among children 0–4 years old in April 2021 and exceeded baseline by June 2021 (a 9% increase over the average monthly values for 2015–2019). Children aged 5–14 years and adults aged 15–34 or ≥80 years showed increases in IPD cases that exceeded baseline values starting in July 2021, with increases also starting in spring 2021. The age distribution and proportion of vaccine-serotype IPD remained comparable to those in previous years, despite lower overall case counts in 2020 and 2021. The percentage change in IPD incidence compared with the previous 5 years was correlated with changes in mobility and with NPI stringency. IPD levels began to return to and exceed seasonal levels in spring and summer 2021 in Germany, following sharp declines in 2020 that coincided with NPIs related to the coronavirus disease 2019 pandemic. Proportions of vaccine serotypes remained largely consistent throughout 2020–2021. Invasive Pneumococcal Disease returned to or exceeded baseline levels in mid-2021 in Germany following substantial decreases in 2020, concurrent with the first wave of the SARS-CoV-2 pandemic. This reemergence was associated with increased mobility and decreased stringency to nonpharmaceutical interventions .
登录
查看更多内容
影响因子：
11.8
作者：
Weinberger DM;Givon-Lavi N;Shemer-Avni Y;Bar-Ziv J;Alonso WJ;Greenberg D;Dagan R
通讯作者：
Dagan R
影响因子：
5.7
作者：
Sender V;Hentrich K;Henriques-Normark B
通讯作者：
Henriques-Normark B
影响因子：
3.7
作者：
Perniciaro, Stephanie;Imoehl, Matthias;van der Linden, Mark
通讯作者：
van der Linden, Mark
DOI：
10.1016/s2589-7500(21)00077-7
发表时间：
2021-06
期刊：
The Lancet. Digital health
影响因子：
--
作者：
Brueggemann AB;Jansen van Rensburg MJ;Shaw D;McCarthy ND;Jolley KA;Maiden MCJ;van der Linden MPG;Amin-Chowdhury Z;Bennett DE;Borrow R;Brandileone MC;Broughton K;Campbell R;Cao B;Casanova C;Choi EH;Chu YW;Clark SA;Claus H;Coelho J;Corcoran M;Cottrell S;Cunney RJ;Dalby T;Davies H;de Gouveia L;Deghmane AE;Demczuk W;Desmet S;Drew RJ;du Plessis M;Erlendsdottir H;Fry NK;Fuursted K;Gray SJ;Henriques-Normark B;Hale T;Hilty M;Hoffmann S;Humphreys H;Ip M;Jacobsson S;Johnston J;Kozakova J;Kristinsson KG;Krizova P;Kuch A;Ladhani SN;Lâm TT;Lebedova V;Lindholm L;Litt DJ;Martin I;Martiny D;Mattheus W;McElligott M;Meehan M;Meiring S;Mölling P;Morfeldt E;Morgan J;Mulhall RM;Muñoz-Almagro C;Murdoch DR;Murphy J;Musilek M;Mzabi A;Perez-Argüello A;Perrin M;Perry M;Redin A;Roberts R;Roberts M;Rokney A;Ron M;Scott KJ;Sheppard CL;Siira L;Skoczyńska A;Sloan M;Slotved HC;Smith AJ;Song JY;Taha MK;Toropainen M;Tsang D;Vainio A;van Sorge NM;Varon E;Vlach J;Vogel U;Vohrnova S;von Gottberg A;Zanella RC;Zhou F
通讯作者：
Zhou F
影响因子：
3.9
作者：
Cucchiari, David;Pericas, Juan M.;Nicolas, David
通讯作者：
Nicolas, David