β-Aminoisobutyric Acid Relates to Favorable Glucose Metabolism through Adiponectin in Adults with Obesity Independent of Prediabetes.
β-Aminoisobutyric Acid Relates to Favorable Glucose Metabolism through Adiponectin in Adults with Obesity Independent of Prediabetes.
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DOI：
10.1155/2023/4618215
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发表时间：
2023
影响因子：
4.3
通讯作者：
Malin, Steven K.
中科院分区：
文献类型：
--
作者：
Faiz, Habiba;Heiston, Emily M.;Malin, Steven K.
β-氨基异丁酸（BAIBA）由骨骼肌分泌，促进胰岛素敏感性、脂肪氧化和抗炎症。虽然据称肥胖人群的BAIBA浓度较低，但没有研究表明糖尿病前期（PD）是否会对肥胖人群的BAIBA浓度产生不同的影响。方法。成人分为正常葡萄糖耐量(NGT, n = 22 (20F)；48.0±2.4年；36.9±1.2 kg/m2)或PD (n = 23 (18F)；54.2±1.6岁；38.4±1.2 kg/m2)。180分钟75 g OGTT用于评估空腹（HOMA-IR（肝脏））和餐后（Matsuda指数（肌肉））胰岛素敏感性以及β细胞功能（倾向指数（DI），葡萄糖刺激的胰岛素分泌调节胰岛素敏感性）。测定白芭的体成分和空腹测量、脂肪氧化（间接量热法）和脂肪因子。结果。NGT和PD具有相似的白ba浓度（1.4±0.1 μM vs. 1.2±0.1 μM, P = 0.23）和脂肪氧化（P = 0.31），尽管NGT的空腹（92.2±1.2 vs. 104.1±3.2 mg/dL, P = 0.002）和tAUC180min葡萄糖（P < 0.001）较PD低。此外，NGT具有较高的餐后胰岛素敏感性（P = 0.01）和较高的总相DIliver （P = 0.003）和DImuscle （P = 0.001）。BAIBA升高与脂联素（r = 0.37, P = 0.02）、脂联素/瘦素比值（r = 0.39, P = 0.01）、180分钟血糖和胰岛素降低相关（r = - 0.31, P = 0.03和r = - 0.39, P = 0.03）。脂联素也与180分钟血糖降低相关（r = - 0.45, P = 0.005），中介分析显示，在控制脂联素后，BAIBA不再是180分钟血糖的显著预测因子（P = 0.08）。结论。虽然BAIBA在NGT和PD之间没有差异，但较高的BAIBA可能与有利的糖代谢有关，可能通过脂联素相关机制。需要进一步的工作来了解运动和/或饮食如何影响与2型糖尿病风险相关的BAIBA。
β-Aminoisobutyric acid (BAIBA) is secreted by skeletal muscle and promotes insulin sensitivity, fat oxidation, and anti-inflammation. While BAIBA is purportedly lower in individuals with obesity, no work has examined if prediabetes (PD) differentially impacts BAIBA concentrations in people with obesity. Methods. Adults were classified as normal glucose tolerant (NGT; n = 22 (20F); 48.0 ± 2.4 yrs; 36.9 ± 1.2 kg/m2) or PD (n = 23 (18F); 54.2 ± 1.6 yrs; 38.4 ± 1.2 kg/m2) based on ADA criteria. A 180-minute 75 g OGTT was used to estimate fasting (HOMA-IR (liver)) and postprandial (Matsuda index (muscle)) insulin sensitivity as well as β-cell function (disposition index (DI), glucose-stimulated insulin secretion adjusted for insulin sensitivity). Body composition and fasting measures of BAIBA, fat oxidation (indirect calorimetry), and adipokines were determined. Results. NGT and PD had similar BAIBA concentrations (1.4 ± 0.1 vs. 1.2 ± 0.1 μM, P = 0.23) and fat oxidation (P = 0.31), despite NGT having lower fasting (92.2 ± 1.2 vs. 104.1 ± 3.2 mg/dL, P = 0.002) and tAUC180min glucose (P < 0.001) compared to PD. Moreover, NGT had higher postprandial insulin sensitivity (P = 0.01) and higher total phase DIliver (P = 0.003) and DImuscle (P = 0.001). Increased BAIBA was associated with adiponectin (r = 0.37, P = 0.02), adiponectin/leptin ratio (r = 0.39, P = 0.01), and lower glucose and insulin at 180 minutes (r = −0.31, P = 0.03 and r = −0.39, P = 0.03, respectively). Adiponectin also correlated with lower glucose at 180 minutes (r = −0.45, P = 0.005), and mediation analysis showed that BAIBA was no longer a significant predictor of glucose at 180 minutes after controlling for adiponectin (P = 0.08). Conclusion. While BAIBA did not differ between NGT and PD, higher BAIBA is related to favorable glucose metabolism, possibly through an adiponectin-related mechanism. Additional work is required to understand how exercise and/or diet impact BAIBA in relation to type 2 diabetes risk.
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影响因子：
6.9
作者：
Begriche, Karima;Massart, Julie;Fromenty, Bernard
通讯作者：
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