Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies.
Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies.
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DOI：
10.1080/17425247.2018.1502267
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发表时间：
2018-08
影响因子：
6.6
通讯作者：
Saleem I
中科院分区：
文献类型：
--
作者：
Osman N;Kaneko K;Carini V;Saleem I
简介：具有独特作用和效力的大分子越来越多地被考虑用于肺部病理学。已经研究了这些大分子通过肺的许多递送策略以改善靶向和总体功效。所涉领域：讨论了从输送装置、制剂战略和具体目标出发的靶向方法。专家意见：虽然大分子是一组异质的分子，但已经在宏观、微观和纳米尺度上研究了许多策略，用于将大分子递送到肺组织的特定部位和细胞。靶向方法已经通过吸入装置和制剂在宏观尺度上使用，但在微观和纳米尺度上的靶向策略仍处于实验室阶段。通过靶向策略的组合，控制肺沉积和沉积后靶向的组合可能是通过肺途径治疗肺部病变的未来方向。
Introduction: Macromolecules with unique effects and potency are increasingly being considered for application in lung pathologies. Numerous delivery strategies for these macromolecules through the lung have been investigated to improve the targeting and overall efficacy. Areas covered: Targeting approaches from delivery devices, formulation strategies and specific targets are discussed. Expert opinion: Although macromolecules are a heterogeneous group of molecules, a number of strategies have been investigated at the macro, micro, and nanoscopic scale for the delivery of macromolecules to specific sites and cells of lung tissues. Targeted approaches are already in use at the macroscopic scale through inhalation devices and formulations, but targeting strategies at the micro and nanoscopic scale are still in the laboratory stage. The combination of controlling lung deposition and targeting after deposition, through a combination of targeting strategies could be the future direction for the treatment of lung pathologies through the pulmonary route.
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DOI：
10.1016/j.omtn.2017.10.010
发表时间：
2017-12-15
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Guo S;Li H;Ma M;Fu J;Dong Y;Guo P
通讯作者：
Guo P
影响因子：
7.3
作者：
Cohn L;Delamarre L
通讯作者：
Delamarre L
影响因子：
1.3
作者：
Boholm, Max;Arvidsson, Rickard
通讯作者：
Arvidsson, Rickard
影响因子：
3.8
作者：
Alfagih, Iman;Kunda, Nitesh;Saleem, Imran Y.
通讯作者：
Saleem, Imran Y.
影响因子：
3.3
作者：
Gibbons, Aileen;McElvaney, Noel G.;Cryan, Sally-Ann
通讯作者：
Cryan, Sally-Ann