Geographic variation of intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and hepatocellular carcinoma in the United States.
Geographic variation of intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and hepatocellular carcinoma in the United States.
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DOI：
10.1371/journal.pone.0120574
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
McGlynn KA
中科院分区：
文献类型：
--
作者：
Altekruse SF;Petrick JL;Rolin AI;Cuccinelli JE;Zou Z;Tatalovich Z;McGlynn KA
肝内（ICC）和肝外胆管癌（ECC）是由胆管中的胆管细胞产生的肿瘤，但ICC被编码为原发性肝癌，而ECC被编码为胆道癌。这些肿瘤的病因尚不清楚。有人认为，ICC 的病因学与另一种肝癌——肝细胞癌 (HCC) 的病因学更为相似，而不是 ECC 的病因学。如果这是真的，那么 ICC 发病率的地理发病模式和趋势应该更类似于 HCC，而不是 ECC。为了检验这一假设，对北美中央癌症登记协会癌症数据文件中的数据进行了分析。发病率和连接点趋势是按人口亚组计算的。绘制了县级发病率图。 ICC 和 ECC 的总体发病率、种族分布、男女比例和高峰年龄比 HCC 更相似。 2000年至2009年间，ECC的年平均发病率有所增加。 2005-2009年间，ICC年平均发病率也有所增加。太平洋地区，特别是夏威夷和阿拉斯加，所有三个癌症地点的发病率都很高。东北部和中西部北部地区的 ICC 和 ECC 发病率也很高，而南部地区的 HCC 发病率也很高。 ICC 和 ECC 之间的人口统计学模式和地理变异比 HCC 之间的相关性更密切，表明 ICC 和 ECC 的病因可能相似。两种肿瘤发病率的增加表明有必要进行进一步的病因学研究。
Intrahepatic (ICC) and extrahepatic cholangiocarcinomas (ECC) are tumors that arise from cholangiocytes in the bile duct, but ICCs are coded as primary liver cancers while ECCs are coded as biliary tract cancers. The etiology of these tumors is not well understood. It has been suggested that the etiology of ICC is more similar to that of another type of liver cancer, hepatocellular carcinoma (HCC), than to the etiology of ECC. If this is true, geographic incidence patterns and trends in ICC incidence should be more similar to that of HCC than ECC. To examine this hypothesis, data from the North American Association of Central Cancer Registries Cancer in North America data file were analyzed. Incidence rates and joinpoint trends were calculated by demographic subgroup. County-level incidence rates were mapped. Overall incidence rates, racial distribution, male:female ratio, and peak ages were more similar between ICC and ECC than with HCC. During 2000–2009, average annual incidence rates of ECC increased. During 2005–2009, average annual ICC incidence rates also increased. High rates for all three cancer sites were found in the Pacific region, particularly Hawaii and Alaska. Rates of ICC and ECC were also high in the Northeast and the upper Midwest, while rates of HCC were high in the South. Demographic patterns and geographical variation were more closely related between ICC and ECC than HCC, suggesting that the etiology of ICC and ECC may be similar. Increasing rates of both tumors suggest that further etiology studies are warranted.
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影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
影响因子：
9.8
作者：
Altekruse, Sean F.;Henley, S. Jane;Cucinelli, James E.;McGlynn, Katherine A.
通讯作者：
McGlynn, Katherine A.
影响因子：
50.5
作者：
Chapman, RW
通讯作者：
Chapman, RW
美国Prevacine时代宫颈癌筛查，发病率，阶段和死亡率的地理分布。
DOI：
10.1158/1055-9965.epi-10-1183
发表时间：
2011-04
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Horner MJ;Altekruse SF;Zou Z;Wideroff L;Katki HA;Stinchcomb DG
通讯作者：
Stinchcomb DG
DOI：
10.1111/j.1440-1746.2012.07207.x
发表时间：
2012-10-01
影响因子：
4.1
作者：
Li, Min;Li, Jinzheng;Gong, Jianping
通讯作者：
Gong, Jianping