Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade.
Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade.
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DOI：
10.7189/jogh.11.15003
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发表时间：
2021
影响因子：
7.2
通讯作者：
Rudan I
中科院分区：
文献类型：
--
作者：
Adeloye D;Agarwal D;Barnes PJ;Bonay M;van Boven JF;Bryant J;Caramori G;Dockrell D;D'Urzo A;Ekström M;Erhabor G;Esteban C;Greene CM;Hurst J;Juvekar S;Khoo EM;Ko FW;Lipworth B;López-Campos JL;Maddocks M;Mannino DM;Martinez FJ;Martinez-Garcia MA;McNamara RJ;Miravitlles M;Pinnock H;Pooler A;Quint JK;Schwarz P;Slavich GM;Song P;Tai A;Watz H;Wedzicha JA;Williams MC;Campbell H;Sheikh A;Rudan I
近几十年来，慢性阻塞性肺疾病（COPD）的全球患病率显着增加。鉴于可用于应对全球健康挑战的资源稀缺，且呼吸系统医学的投资相对不足，因此确定全球慢性阻塞性肺病的研究重点非常重要。在本文中，我们的目标是确定未来 10 年内需要解决的一系列慢性阻塞性肺病研究重点，以大幅减少慢性阻塞性肺病的全球影响。我们采用了儿童健康和营养研究计划 (CHNRI) 方法来确定全球慢性阻塞性肺病研究重点。 62位专家贡献了230个研究想法，由34名研究人员根据六个预先定义的标准进行评分：责任性、有效性、可行性、可交付性、减轻负担和公平性。最重要的研究重点是需要新的有效策略来支持戒烟。在前 20 个总体研究重点中，有 6 个重点关注可行且具有成本效益的肺康复服务和获取，特别是在初级/社区护理和资源匮乏的环境中。十大总体优先事项中的三个要求在资源匮乏的初级保健机构中研究改进慢性阻塞性肺病的筛查和准确的诊断方法。获得支持的进一步想法包括更好地了解慢性阻塞性肺病的危险因素，为资源匮乏地区的卫生工作者和医生制定有效的培训计划，以及评估鼓励身体活动的新干预措施。专家们一致认为，未来十年减少慢性阻塞性肺病需要解决的最紧迫的可行研究问题是慢性阻塞性肺病的预防、诊断和康复，特别是在资源匮乏的环境中。预期收益最大的是低收入和中等收入国家 (LMIC)，因为绝大多数慢性阻塞性肺病死亡发生在这些国家。这一系统性国际进程确定的研究重点应告知并激励政策制定者、资助者和研究人员支持和开展研究，以减轻慢性阻塞性肺病的全球负担。
The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-invested in, it is important to define research priorities for COPD globally. In this paper, we aim to identify a ranked set of COPD research priorities that need to be addressed in the next 10 years to substantially reduce the global impact of COPD. We adapted the Child Health and Nutrition Research Initiative (CHNRI) methodology to identify global COPD research priorities. 62 experts contributed 230 research ideas, which were scored by 34 researchers according to six pre-defined criteria: answerability, effectiveness, feasibility, deliverability, burden reduction, and equity. The top-ranked research priority was the need for new effective strategies to support smoking cessation. Of the top 20 overall research priorities, six were focused on feasible and cost-effective pulmonary rehabilitation delivery and access, particularly in primary/community care and low-resource settings. Three of the top 10 overall priorities called for research on improved screening and accurate diagnostic methods for COPD in low-resource primary care settings. Further ideas that drew support involved a better understanding of risk factors for COPD, development of effective training programmes for health workers and physicians in low resource settings, and evaluation of novel interventions to encourage physical activity. The experts agreed that the most pressing feasible research questions to address in the next decade for COPD reduction were on prevention, diagnosis and rehabilitation of COPD, especially in low resource settings. The largest gains should be expected in low- and middle-income countries (LMIC) settings, as the large majority of COPD deaths occur in those settings. Research priorities identified by this systematic international process should inform and motivate policymakers, funders, and researchers to support and conduct research to reduce the global burden of COPD.
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影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
7.5
作者：
Celli, Bartolome R;Decramer, Marc;Wedzicha, Jadwiga A;Wilson, Kevin C;Agusti, Alvar A;Criner, Gerard J;MacNee, William;Make, Barry J;Rennard, Stephen I;Stockley, Robert A;Vogelmeier, Claus;Anzueto, Antonio;Au, David H;Barnes, Peter J;Burgel, Pierre-Regis;Calverley, Peter M;Casanova, Ciro;Clini, Enrico M;Cooper, Christopher B;Coxson, Harvey O;Dusser, Daniel J;Fabbri, Leonardo M;Fahy, Bonnie;Ferguson, Gary T;Fisher, Andrew;Fletcher, Monica J;Hayot, Maurice;Hurst, John R;Jones, Paul W;Mahler, Donald A;Maltais, Francois;Mannino, David M;Martinez, Fernando J;Miravitlles, Marc;Meek, Paula M;Papi, Alberto;Rabe, Klaus F;Roche, Nicolas;Sciurba, Frank C;Sethi, Sanjay;Siafakas, Nikos;Sin, Don D;Soriano, Joan B;Stoller, James K;Tashkin, Donald P;Troosters, Thierry;Verleden, Geert M;Verschakelen, Johny;Vestbo, Jorgen;Walsh, John W;Washko, George R;Wise, Robert A;Wouters, Emiel F M;ZuWallack, Richard L
通讯作者：
ZuWallack, Richard L
影响因子：
64.8
作者：
Collins, Pamela Y.;Patel, Vikram;Joestl, Sarah S.;March, Dana;Insel, Thomas R.;Daar, Abdallah S.
通讯作者：
Daar, Abdallah S.
影响因子：
5.8
作者：
Brakema, Evelyn A.;Tabyshova, Aizhamal;Williams, Sian
通讯作者：
Williams, Sian
影响因子：
82.9
作者：
Furman, David;Campisi, Judith;Slavich, George M.
通讯作者：
Slavich, George M.