Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine.
Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine.
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DOI：
10.1016/j.gie.2009.07.007
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发表时间：
2010-02
影响因子：
7.7
通讯作者：
Tearney, Guillermo J.
中科院分区：
文献类型：
--
作者：
Suter, Melissa J.;Jillella, Priyanka A.;Vakoc, Benjamin J.;Halpern, Elkan F.;Mino-Kenudson, Mari;Lauwers, Gregory Y.;Bouma, Brett E.;Nishioka, Norman S.;Tearney, Guillermo J.
随机活检食管监测可能会出现采样误差，导致诊断的不确定性。光频域成像 (OFDI) 是一种高速三维内窥镜显微镜技术。当通过球囊中心导管部署时，OFDI 可以在大约 2 分钟内自动对整个远端食管（6.0 厘米长）进行成像。测试用于引导活检的新平台，该平台允许操作员在 OFDI 数据集上选择感兴趣的目标区域，然后使用激光在相应位置标记食道。具体目标包括确定最佳激光参数、测试激光打标过程的准确性、评估激光标记的内窥镜可见度以及评估激光产生的粘膜损伤量。在五只猪身上进行了体内实验研究。马萨诸塞州总医院。成功率，包括激光标记的内窥镜可见度和选定目标位置的激光标记过程的准确性，以及激光标记造成的热损伤的程度。通过内窥镜检查可以看到所有激光引起的标记。目标位置正确标记，成功率为 97.07%（95% CI，89.8%-99.7%）。热损伤仅限于粘膜表层，观察到在 2 天内部分愈合。通过人工放置目标来模拟病理学的动物研究。该研究表明，对综合 OFDI 数据集中识别的食管部位进行激光标记是可行的，并且可以以足够的准确度、精度和可见性进行，以指导体内活检。
Random biopsy esophageal surveillance can be subject to sampling errors, resulting in diagnostic uncertainty. Optical frequency domain imaging (OFDI) is a high-speed, three-dimensional endoscopic microscopy technique. When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes. To test a new platform for guided biopsy that allows the operator to select target regions of interest on an OFDI dataset, and then use a laser to mark the esophagus at corresponding locations. The specific goals include determining the optimal laser parameters, testing the accuracy of the laser marking process, evaluating the endoscopic visibility of the laser marks, and assessing the amount of mucosal damage produced by the laser. Experimental study conducted in five swine in vivo. Massachusetts General Hospital. Success rate, including endoscopic visibility of laser marks and accuracy of the laser marking process for selected target sites, and extent of the thermal damage caused by the laser marks. All of the laser-induced marks were visible by endoscopy. Target locations were correctly marked with a success rate of 97.07% (95% CI, 89.8%-99.7%). Thermal damage was limited to the superficial layers of the mucosa and was observed to partially heal within 2 days. An animal study with artificially placed targets to simulate pathology. The study demonstrates that laser marking of esophageal sites identified in comprehensive OFDI datasets is feasible and can be performed with sufficient accuracy, precision, and visibility to guide biopsy in vivo.
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影响因子：
7.7
作者：
Suter, Melissa J.;Vakoc, Benjamin J.;Yachimski, Patrick S.;Shishkov, Milen;Lauwers, Gregory Y.;Mino-Kenudson, Mari;Bouma, Brett E.;Nishioka, Norman S.;Tearney, Guillermo J.
通讯作者：
Tearney, Guillermo J.
影响因子：
7.7
作者：
Isenberg, G;Sivak, MV;Rollins, A
通讯作者：
Rollins, A
影响因子：
7.7
作者：
Vakoc, Benjamin J.;Shishko, Milen;Bouma, Brett E.
通讯作者：
Bouma, Brett E.
影响因子：
7.7
作者：
YANG, R;NARITOKU, W;LAINE, L
通讯作者：
LAINE, L
影响因子：
3.8
作者：
Yun, SH;Tearney, GJ;Bouma, BE
通讯作者：
Bouma, BE