A Comprehensive Review of Detection Methods for SARS-CoV-2.
A Comprehensive Review of Detection Methods for SARS-CoV-2.
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DOI：
10.3390/microorganisms9020232
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发表时间：
2021-01-22
期刊：
影响因子：
4.5
通讯作者：
Cucchiarini M
中科院分区：
文献类型：
--
作者：
Eftekhari A;Alipour M;Chodari L;Maleki Dizaj S;Ardalan M;Samiei M;Sharifi S;Zununi Vahed S;Huseynova I;Khalilov R;Ahmadian E;Cucchiarini M
近日，由SARS-CoV-2病毒引起的冠状病毒病2019年(新冠肺炎)在中国暴发并随后在全球蔓延，造成无数人感染和死亡，扰乱了正常的社交活动。目前，诊断SARS-CoV-2感染的技术有多种，各有优缺点。本文综述了逆转录聚合酶链式反应(RT-PCR)、血清学检测、护理点检测、智能手机传染病监测、基于纳米技术的方法、生物传感器、基于扩增的基因组测序、智能手机和基于废水的流行病学(WBE)等也可用于SARS-CoV-2检测的方法。此外，我们还讨论了这些检测方法的原理、优缺点，并强调了开发更多的早期和快速检测SARS-CoV-2的技术和产品的潜在方法。
Recently, the outbreak of the coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, in China and its subsequent spread across the world has caused numerous infections and deaths and disrupted normal social activity. Presently, various techniques are used for the diagnosis of SARS-CoV-2 infection, with various advantages and weaknesses to each. In this paper, we summarize promising methods, such as reverse transcription-polymerase chain reaction (RT-PCR), serological testing, point-of-care testing, smartphone surveillance of infectious diseases, nanotechnology-based approaches, biosensors, amplicon-based metagenomic sequencing, smartphone, and wastewater-based epidemiology (WBE) that can also be utilized for the detection of SARS-CoV-2. In addition, we discuss principles, advantages, and disadvantages of these detection methods, and highlight the potential methods for the development of additional techniques and products for early and fast detection of SARS-CoV-2.
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