Using the electrically-evoked compound action potential (ECAP) interphase gap effect to select electrode stimulation sites in cochlear implant users.
Using the electrically-evoked compound action potential (ECAP) interphase gap effect to select electrode stimulation sites in cochlear implant users.
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DOI：
10.1016/j.heares.2021.108257
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发表时间：
2021-07
期刊：
影响因子：
2.8
通讯作者：
Pfingst BE
中科院分区：
文献类型：
--
作者：
Schvartz-Leyzac KC;Zwolan TA;Pfingst BE
耳蜗植入动物的研究表明，IPG效应对ECAP生长功能的影响（即当间期间隙（IPG）增加时，ECAP振幅生长函数（AGF）斜率或峰值振幅的变化幅度）可以用来估计电极刺激和记录位点附近螺旋神经节神经元（sgn）的密度。在人类中，同样的ECAP IPG效应测量与语音识别性能相关。本研究考察了基于IPG效应选择刺激电极位置的有效性，以提高CI用户在语音识别任务中的表现。我们测量了成年（18岁）CI使用者（N= 18耳）ECAP IPG效应的峰值振幅，并创建了实验程序来刺激具有最高或最低ECAP IPG效应峰值振幅的电极。实验对象还听了一个没有关闭电极的节目。在受试者耳朵的一个子集（11/18）中，我们比较了实验方案与术后计算机断层扫描（CT）扫描之间的性能差异，以检查可能影响电极位置选择方法有效性的潜在因素。对于有噪声的句子，当受试者收听刺激ECAP峰幅最高的电极而不是最低的电极的实验节目时，他们的平均表现更好。在辅音识别任务中，对辅音位置线索的传递和感知也有类似的模式。然而，平均而言，收听IPG效应值较高的节目时的表现与所有电极都激活时的表现相同。结果还表明，在使用基于ecap的电极选址程序以优化CI性能时，应考虑标量位置（鼓室或前庭）。
Studies in cochlear implanted animals show that the IPG Effect for ECAP growth functions (i.e., the magnitude of the change in ECAP amplitude growth function (AGF) slope or peak amplitude when the interphase gap (IPG) is increased) can be used to estimate the densities of spiral ganglion neurons (SGNs) near the electrode stimulation and recording sites. In humans, the same ECAP IPG Effect measures correlate with speech recognition performance. The present study examined the efficacy of selecting electrode sites for stimulation based on the IPG Effect, in order to improve performance of CI users on speech recognition tasks. We measured the ECAP IPG Effect for peak amplitude in adult (>18 years old) CI users (N= 18 ears), and created experimental programs to stimulate electrodes with either the highest or lowest ECAP IPG Effect for peak amplitude. Subjects also listened to a program without any electrodes deactivated. In a subset of subject ears (11/18), we compared performance differences between the experimental programs to post-operative computerized tomography (CT) scans to examine underlying factors that might contribute to the efficacy of an electrode site-selection approach. For sentences-in-noise, average performance was better when subjects listened to the experimental program that stimulated electrodes with the highest rather than the lowest IPG Effect for ECAP peak amplitude. A similar pattern was noted for transmission and perception of consonant place cues in a consonant recognition task. However, on average, performance when listening to a program with higher IPG Effect values was equal to that when listening with all electrodes activated. Results also suggest that scalar location (scala tympani or vestibuli) should be considered when using an ECAP-based electrode site-selection procedure to optimize CI performance.
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影响因子：
2.1
作者：
Degen, Chantal Vanessa;Buechner, Andreas;Lenarz, Thomas
通讯作者：
Lenarz, Thomas
影响因子：
2.1
作者：
Davis, Timothy J.;Zhang, Dongqing;Noble, Jack H.
通讯作者：
Noble, Jack H.
影响因子：
2.4
作者：
MILLER, GA;NICELY, PE
通讯作者：
NICELY, PE
DOI：
10.1097/mao.0b013e3181ec1d92
发表时间：
2010-09
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
--
作者：
Kim JR;Abbas PJ;Brown CJ;Etler CP;O'Brien S;Kim LS
通讯作者：
Kim LS
影响因子：
1.2
作者：
Brown CJ;Abbas PJ;Etlert CP;O'Brient S;Oleson JJ
通讯作者：
Oleson JJ