Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms.
Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms.
复制标题
周围炎症和血脑屏障破坏：影响和机制。
DOI：
10.1111/cns.13569
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发表时间：
2021-01
影响因子：
5.5
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Huang X;Hussain B;Chang J
血脑屏障(BBB)是分隔中枢神经系统(CNS)和外周循环的重要生理屏障，外周循环中含有炎症介质和免疫细胞。血脑屏障调节血管和脑实质之间的细胞和分子交换。血脑屏障的正常功能对大脑的动态平衡和正常功能至关重要。已有研究表明，外周炎症可通过多种途径破坏血脑屏障，导致不同的中枢神经系统疾病。最近，临床研究也发现了SARS-CoV-2感染和嵌合抗原受体(CAR)-T细胞治疗后的中枢神经系统并发症，两者都导致了循环中的细胞因子风暴。因此，阐明外周炎症导致血脑屏障破坏的机制将为在外周炎症性疾病加重的情况下保护中枢神经系统提供重要依据。在本综述中，我们首先概述了血脑屏障的生理特性，它使中枢神经系统成为免疫特权器官。然后我们讨论外周炎症引起的血脑屏障破坏与各种中枢神经系统疾病的相关性。最后，我们阐述了破坏血脑屏障的外周炎症的各种因素和机制。
The blood–brain barrier (BBB) is an important physiological barrier that separates the central nervous system (CNS) from the peripheral circulation, which contains inflammatory mediators and immune cells. The BBB regulates cellular and molecular exchange between the blood vessels and brain parenchyma. Normal functioning of the BBB is crucial for the homeostasis and proper function of the brain. It has been demonstrated that peripheral inflammation can disrupt the BBB by various pathways, resulting in different CNS diseases. Recently, clinical research also showed CNS complications following SARS‐CoV‐2 infection and chimeric antigen receptor (CAR)‐T cell therapy, which both lead to a cytokine storm in the circulation. Therefore, elucidation of the mechanisms underlying the BBB disruption induced by peripheral inflammation will provide an important basis for protecting the CNS in the context of exacerbated peripheral inflammatory diseases. In the present review, we first summarize the physiological properties of the BBB that makes the CNS an immune‐privileged organ. We then discuss the relevance of peripheral inflammation‐induced BBB disruption to various CNS diseases. Finally, we elaborate various factors and mechanisms of peripheral inflammation that disrupt the BBB.
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影响因子：
3.7
作者：
Cardoso FL;Kittel A;Veszelka S;Palmela I;Tóth A;Brites D;Deli MA;Brito MA
通讯作者：
Brito MA
影响因子：
56.9
作者：
Coureuil, Mathieu;Mikaty, Guillain;Nassif, Xavier
通讯作者：
Nassif, Xavier
影响因子：
5.5
作者：
Chen, Wei;Ju, Xing-Zhu;Chen, Jia-Wei
通讯作者：
Chen, Jia-Wei
影响因子：
4.6
作者：
Biesmans S;Meert TF;Bouwknecht JA;Acton PD;Davoodi N;De Haes P;Kuijlaars J;Langlois X;Matthews LJ;Ver Donck L;Hellings N;Nuydens R
通讯作者：
Nuydens R
DOI：
10.1073/pnas.0808698106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Argaw, Azeb Tadesse;Gurfein, Blake T.;John, Gareth R.
通讯作者：
John, Gareth R.