How to rewire the host cell: A home improvement guide for intracellular bacteria.
How to rewire the host cell: A home improvement guide for intracellular bacteria.
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DOI：
10.1083/jcb.201701095
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发表时间：
2017-12-04
期刊：
影响因子：
--
通讯作者：
Mukherjee S
中科院分区：
文献类型：
--
作者：
Cornejo E;Schlaermann P;Mukherjee S
Cornejo，Schlaermann和Mukherjee讨论了细胞内细菌如何篡夺宿主细胞以及细胞生物学家可以从这些方法中学到什么。细胞内细菌病原体已经开发出多种策略来在真核细胞内产生小生境，使它们能够存活和增殖。在宿主体内安家提供了许多优势;然而，细胞内细菌还必须克服许多挑战，例如解除先天免疫信号传导和获取宿主营养供应。进入细胞并避免降解只是成功的细胞内生活方式的开始。为了建立这些复制小生境，胞内病原体分泌各种毒力蛋白，称为效应子，以操纵宿主细胞信号传导途径并破坏宿主防御机制。许多效应物模仿宿主酶，而另一些则执行完全新颖的酶功能。已经做了大量的工作来了解细胞内细菌如何操纵膜运输途径。在这篇综述中，我们专注于细胞内细菌病原体如何靶向先天免疫信号传导，未折叠蛋白反应，自噬和细胞代谢，并利用这些途径发挥其优势。我们还讨论了细菌病原体如何通过直接修饰组蛋白或劫持泛素化机制来控制几种宿主信号通路来改变宿主基因表达。
Cornejo, Schlaermann, and Mukherjee discuss how intracellular bacteria usurp host cells and what cell biologists can learn from these methods. Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate. Making a home inside the host offers many advantages; however, intracellular bacteria must also overcome many challenges, such as disarming innate immune signaling and accessing host nutrient supplies. Gaining entry into the cell and avoiding degradation is only the beginning of a successful intracellular lifestyle. To establish these replicative niches, intracellular pathogens secrete various virulence proteins, called effectors, to manipulate host cell signaling pathways and subvert host defense mechanisms. Many effectors mimic host enzymes, whereas others perform entirely novel enzymatic functions. A large volume of work has been done to understand how intracellular bacteria manipulate membrane trafficking pathways. In this review, we focus on how intracellular bacterial pathogens target innate immune signaling, the unfolded protein response, autophagy, and cellular metabolism and exploit these pathways to their advantage. We also discuss how bacterial pathogens can alter host gene expression by directly modifying histones or hijacking the ubiquitination machinery to take control of several host signaling pathways.
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DOI：
10.1038/nri.2016.100
发表时间：
2016-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Cadwell K
通讯作者：
Cadwell K
DOI：
10.1126/science.1227026
发表时间：
2012-11-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
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影响因子：
6.7
作者：
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通讯作者：
Ivanov, Stanimir S.
影响因子：
6.7
作者：
Archer KA;Durack J;Portnoy DA
通讯作者：
Portnoy DA
影响因子：
30.5
作者：
Arbibe, Laurence;Kim, Dong Wook;Sansonetti, Philippe J.
通讯作者：
Sansonetti, Philippe J.