Intrahepatic cholestasis of pregnancy and maternal dyslipidemia: a systematic review and meta-analysis.
Intrahepatic cholestasis of pregnancy and maternal dyslipidemia: a systematic review and meta-analysis.
复制标题
妊娠期肝内胆汁淤积症与母体血脂异常：一项系统综述和荟萃分析。
DOI：
10.1111/aogs.14380
复制
发表时间：
2022-07
影响因子：
4.3
通讯作者：
Wang, Xiaodong
中科院分区：
文献类型：
--
作者：
Zhan, Yongchi;Xu, Tingting;Chen, Tiantian;Wang, Xiaodong
妊娠期肝内胆汁淤积症（ICP）与母体脂质代谢之间的关系尚不清楚。本系统性综述和Meta分析旨在评价ICP与母体脂质代谢之间的相关性。我们系统检索了Medline、Embase和科克伦图书馆（截至2021年12月11日），以识别研究ICP和母体血浆脂质浓度的相关研究。使用随机效应模型计算加权平均差（WMD）和95%置信区间（CI）。进行亚组分析以确定异质性的潜在来源。使用漏斗图和Egger和Begg检验对潜在的发表偏倚进行了检验。该Meta分析已在PROSPERO注册（CRD 42021293783）。11项研究被纳入本定性分析。对最终纳入的9项研究的数据进行随机效应Meta分析（n = 786名参与者）显示ICP与孕产妇血脂异常（甘油三酯水平升高）之间存在显着相关性（WMD，0.67 mmol/L; 95% CI 0.39-0.95; P < 0.001），总胆固醇（WMD，1.08 mmol/L; 95% CI 0.58-1.58; P < 0.001），低密度脂蛋白胆固醇（WMD，1.08 mmol/L; 95% CI 0.53-1.64; P < 0.001），并降低高密度脂蛋白胆固醇水平（WMD，−0.38 mmol/L; 95% CI −0.53至−0.23; P < 0.001）vs正常妊娠。本研究的结果支持ICP和母体血脂异常之间的关联。与正常妊娠相比，ICP妊娠存在脂质代谢失调。
The association between intrahepatic cholestasis of pregnancy (ICP) and maternal lipid metabolism remains unknown. This systematic review and meta‐analysis aimed to evaluate the association between ICP and maternal lipid metabolism. We systematically searched Medline, Embase and the Cochrane Library (up to December 11, 2021) to identify relevant studies that investigated ICP and maternal plasma lipid concentrations. The weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated using random‐effects models. A subgroup analysis was conducted to identify the potential sources of heterogeneity. Potential publication bias was tested using funnel plots and the Egger's and Begg's tests. This meta‐analysis was registered with PROSPERO (CRD42021293783). Eleven studies were included in this qualitative analysis. A random‐effects meta‐analysis of data from the final included nine studies (n = 786 participants) showed a significant association between ICP and maternal dyslipidemia, with elevated levels of triglycerides (WMD, 0.67 mmol/L; 95% CI 0.39–0.95; P < 0.001), total cholesterol (WMD, 1.08 mmol/L; 95% CI 0.58–1.58; P < 0.001), low‐density lipoprotein cholesterol (WMD, 1.08 mmol/L; 95% CI 0.53–1.64; P < 0.001), and reduced high‐density lipoprotein cholesterol level (WMD, −0.38 mmol/L; 95% CI −0.53 to −0.23; P < 0.001) vs normal pregnancies. The present study's findings support an association between ICP and maternal dyslipidemia. ICP pregnancies have dysregulated lipid metabolism vs normal pregnancies.
登录
查看更多内容
影响因子：
16.2
作者：
Martineau, Marcus G.;Raker, Christina;Williamson, Catherine
通讯作者：
Williamson, Catherine
DOI：
10.1016/j.ejogrb.2016.06.019
发表时间：
2016-08-01
影响因子：
2.6
作者：
Hao, Z. M.;Ye, Y. F.;Ye, X. L.
通讯作者：
Ye, X. L.
影响因子：
7.2
作者：
Dann, AT;Kenyon, AP;Tribe, RM
通讯作者：
Tribe, RM
影响因子：
15.9
作者：
Ma, K;Saha, PK;Moore, DD
通讯作者：
Moore, DD
影响因子：
3.5
作者：
Axelsen, Silja M.;Kampmann, Ulla;Fuglsang, Jens
通讯作者：
Fuglsang, Jens