Antimicrobial Monomers for Polymeric Dental Restoratives: Cytotoxicity and Physicochemical Properties.
Antimicrobial Monomers for Polymeric Dental Restoratives: Cytotoxicity and Physicochemical Properties.
复制标题
DOI：
10.3390/jfb9010020
复制
发表时间：
2018-02-27
影响因子：
4.8
通讯作者：
Skrtic D
中科院分区：
文献类型：
--
作者：
Bienek DR;Frukhtbeyn SA;Giuseppetti AA;Okeke UC;Skrtic D
下一代聚合物牙修复体的一个趋势是结合多功能功能来调节微生物生长和牙表面再矿化。合成了可聚合的2-（甲基丙烯酰氧基）-N-（2-（甲基丙烯酰氧基）乙基）-N，N-二甲基-1-溴化胺（IDMA1）和N，N ' -（[1,1 ' -联苯]-2,2 ' -二基双（亚甲基））-2（2-（甲基丙烯酰氧基）-N，N-二甲基-1-氨基）溴化胺（IDMA2），用于双功能抗菌和再矿化复合材料，用乙醇-二乙醚-己烷溶剂体系进行了纯化，并通过核磁共振（1H和13C NMR）谱、质谱验证。傅里叶变换红外光谱。当掺入光固化聚氨酯二甲基丙烯酸酯(UDMA)/聚乙二醇扩展UDMA (PEG-U)/ 2-羟甲基丙烯酸乙酯（EHMA）（指定的UPE）树脂中时，idma不影响树脂整体的亲疏水平衡（水接触角为60.8-65.5°）。含idma共聚物及其无定形磷酸钙（ACP）复合材料的乙烯基转化率（DVC）持续较高（分别高达5%和20%），在IDMA2配方中达到92.5%。值得注意的是，这些高DVCs值是在聚合应力没有过度增加的情况下获得的。观察到的UPE-IDMA ACP复合材料双轴弯曲强度的降低不应该阻止这些材料作为多功能V级修复材料的进一步评估。在与人类牙龈成纤维细胞直接接触时，在生物学上相关的浓度下，idma不会对细胞活力或代谢活性产生不利影响。离子释放表明复合材料具有较强的再矿化潜力。上述早期生物相容性和物理化学测试证明了对这些实验材料进行进一步评估以确定适合临床试验的配方是合理的。成功完井有望产生一种具有良好控制生物功能的新型修复剂，其物理化学、机械和生物学性能将优于传统的V类修复剂。
A trend for the next generation of polymeric dental restoratives is to incorporate multifunctional capabilities to regulate microbial growth and remineralize tooth surfaces. Polymerizable 2-(methacryloyloxy)-N-(2-(methacryloyloxy)ethyl)-N,N-dimethylethan-1-aminium bromide (IDMA1) and N,N′-([1,1′-biphenyl]-2,2′-diylbis(methylene))bis(2-(methacryloyloxy)-N,N-dimethylethan-1-aminium) bromide (IDMA2), intended for utilization in bi-functional antimicrobial and remineralizing composites, were synthesized, purified with an ethanol-diethyl ether-hexane solvent system, and validated by nuclear magnetic resonance (1H and 13C NMR) spectroscopy, mass spectrometry, and Fourier-transform infrared spectroscopy. When incorporated into light-curable urethane dimethacrylate (UDMA)/polyethylene glycol-extended UDMA (PEG-U)/ethyl 2-(hydroxymethyl)acrylate (EHMA) (assigned UPE) resins, IDMAs did not affect the overall resins’ hydrophilicity/hydrophobicity balance (water contact angle: 60.8–65.5°). The attained degrees of vinyl conversion (DVC) were consistently higher in both IDMA-containing copolymers and their amorphous calcium phosphate (ACP) composites (up to 5% and 20%, respectively) reaching 92.5% in IDMA2 formulations. Notably, these high DVCs values were attained without an excessive increase in polymerization stress. The observed reduction in biaxial flexure strength of UPE-IDMA ACP composites should not prevent further evaluation of these materials as multifunctional Class V restoratives. In direct contact with human gingival fibroblasts, at biologically relevant concentrations, IDMAs did not adversely affect cell viability or their metabolic activity. Ion release from the composites was indicative of their strong remineralization potential. The above, early-phase biocompatibility and physicochemical tests justify further evaluation of these experimental materials to identify formulation(s) suitable for clinical testing. Successful completion is expected to yield a new class of restoratives with well-controlled bio-function, which will physicochemically, mechanically, and biologically outperform the conventional Class V restoratives.
登录
查看更多内容
影响因子：
6.2
作者：
Chen, CZS;Beck-Tan, NC;Cooper, SL
通讯作者：
Cooper, SL
影响因子：
6.2
作者：
Lee, SB;Koepsel, RR;Russell, AJ
通讯作者：
Russell, AJ
影响因子：
2.9
作者：
Antonucci, J. M.;Regnault, W. F.;Skrtic, D.
通讯作者：
Skrtic, D.
影响因子：
4.4
作者：
Imazato, S;Tarumi, H;Ebisu, S
通讯作者：
Ebisu, S
影响因子：
3.6
作者：
Mazzanti, Andrea;Lunazzi, Lodovico;Anderson, J. Edgar
通讯作者：
Anderson, J. Edgar