Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system.
Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system.
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DOI：
10.1088/1741-2552/ab7030
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发表时间：
2020-03-12
影响因子：
4
通讯作者：
Purcell E
中科院分区：
文献类型：
--
作者：
Thompson CH;Riggins TE;Patel PR;Chestek CA;Li W;Purcell E
电极设计的创新已经产生了无数新的和创造性的策略，用于将神经系统与更柔软、侵入性更小、分布更广泛的部位连接，并具有高空间分辨率。然而，尽管在研究和临床应用中植入电极阵列的使用快速增长，但对于中枢神经系统（CNS）中生物相容性慢性记录接口的设计，还没有广泛接受的指导原则。研究表明，器械的结构和柔性在确定有效组织整合方面发挥重要作用：器械特征尺寸（从“亚”细胞尺度到“超”细胞尺度，<10 μm到>100 μm）、杨氏模量和弯曲模量均被确定为设计的关键特征。然而，在这些设计的基本动机方面，该领域仍然存在重大的知识差距：（1）系统研究器械设计特征之间的关系（材料、架构、灵活性）、生物整合和信号质量需要执行，包括控制设计特征之间的相互作用效应，（2）需要确定成功的基准（生物整合、记录性能、寿命、稳定性），和（3）用户结果，特别是支持特定设计或电极修改的结果，需要在实验室间复制。最后，需要考虑诸如系留、站点阻抗和插入方法等因素的辅助效应。在这里，我们简要回顾了迄今为止观察到的器械设计对组织整合和性能的影响，然后强调需要对这些影响进行全面和系统的测试。
Innovation in electrode design has produced a myriad of new and creative strategies for interfacing the nervous system with softer, less invasive, more broadly distributed sites with high spatial resolution. However, despite rapid growth in the use of implanted electrode arrays in research and clinical applications, there are no broadly accepted guiding principles for the design of biocompatible chronic recording interfaces in the central nervous system (CNS). Studies suggest that the architecture and flexibility of devices play important roles in determining effective tissue integration: device feature dimensions (varying from ‘sub’- to ‘supra’-cellular scales, <10 μm to >100 μm), Young’s modulus, and bending modulus have all been identified as key features of design. However, critical knowledge gaps remain in the field with respect to the underlying motivation for these designs: (1) a systematic study of the relationship between device design features (materials, architecture, flexibility), biointegration, and signal quality needs to be performed, including controls for interaction effects between design features, (2) benchmarks for success need to be determined (biological integration, recording performance, longevity, stability), and (3) user results, particularly those that champion a specific design or electrode modification, need to be replicated across laboratories. Finally, the ancillary effects of factors such as tethering, site impedance and insertion method need to be considered. Here, we briefly review observations to-date of device design effects on tissue integration and performance, and then highlight the need for comprehensive and systematic testing of these effects moving forward.
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影响因子：
4
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
通讯作者：
Shenoy KV
影响因子：
5
作者：
Capadona, Jeffrey R.;Tyler, Dustin J.;Weder, Christoph
通讯作者：
Weder, Christoph
影响因子：
3.4
作者：
Chauvet, D.;Imbault, M.;Tanter, M.
通讯作者：
Tanter, M.
影响因子：
8.4
作者：
Cui, XY;Martin, DC
通讯作者：
Martin, DC
影响因子：
--
作者：
BRINEN, JS;MELERA, A
通讯作者：
MELERA, A