Glycogen synthase kinase 3 beta: can it be a target for oral cancer.
Glycogen synthase kinase 3 beta: can it be a target for oral cancer.
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DOI：
10.1186/1476-4598-9-144
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发表时间：
2010-06-11
期刊：
影响因子：
37.3
通讯作者：
Mishra R
中科院分区：
文献类型：
--
作者：
Mishra R
尽管口腔癌的治疗方法取得了进展，但在过去的三十年里，患者的预后只有轻微的改善。频繁的治疗失败是由于未能控制肿瘤的复发和转移。这些失败表明，应该确定新的靶点来逆转口腔上皮异型增生病变。最近的研究表明，糖原合成酶激酶3β(GSK3β)在多种人类癌症中发挥着积极的作用，既可以作为肿瘤抑制因子，也可以作为肿瘤促进剂。Gsk3β是一种丝氨酸/苏氨酸蛋白激酶，越来越多的证据表明它在口腔癌中是一种肿瘤抑制因子。证据表明，口腔癌中控制转录、加速细胞周期进展、激活侵袭/转移和抗凋亡的关键因素与Gsk3β对这些因素的调节之间存在联系。此外，GSK3β上游的主要激酶及其致癌活性被几种口腔癌病因激活，支持这一假说。尽管有这些证据，但科学界尚未对Gsk3β在口腔癌中的作用及其治疗潜力进行详细分析。这篇综述的重点是讨论GSK3β的多种作用，它在控制不同致癌事件中的可能作用，以及它如何在口腔癌中被靶向。
Despite progress in treatment approaches for oral cancer, there has been only modest improvement in patient outcomes in the past three decades. The frequent treatment failure is due to the failure to control tumor recurrence and metastasis. These failures suggest that new targets should be identified to reverse oral epithelial dysplastic lesions. Recent developments suggest an active role of glycogen synthase kinase 3 beta (GSK3 β) in various human cancers either as a tumor suppressor or as a tumor promoter. GSK3β is a Ser/Thr protein kinase, and there is emerging evidence that it is a tumor suppressor in oral cancer. The evidence suggests a link between key players in oral cancer that control transcription, accelerated cell cycle progression, activation of invasion/metastasis and anti-apoptosis, and regulation of these factors by GSK3β. Moreover, the major upstream kinases of GSK3β and their oncogenic activation by several etiological agents of oral cancer support this hypothesis. In spite of all this evidence, a detailed analysis of the role of GSK3β in oral cancer and of its therapeutic potential has yet to be conducted by the scientific community. The focus of this review is to discuss the multitude of roles of GSK3β, its possible role in controlling different oncogenic events and how it can be targeted in oral cancer.
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影响因子：
3.3
作者：
Bánkfalvi, A;Krassort, M;Piffkó, J
通讯作者：
Piffkó, J
影响因子：
45.3
作者：
Clayman, GL;El-Naggar, AK;Goepfert, H
通讯作者：
Goepfert, H
影响因子：
1.9
作者：
Baral, R;Patnaik, S;Das, BR
通讯作者：
Das, BR
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
DOI：
10.1158/1078-0432.ccr-09-1352
发表时间：
2009-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Arun P;Brown MS;Ehsanian R;Chen Z;Van Waes C
通讯作者：
Van Waes C