Heritability of quantitative traits associated with type 2 diabetes mellitus in large multiplex families from South India.
Heritability of quantitative traits associated with type 2 diabetes mellitus in large multiplex families from South India.
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DOI：
10.1016/j.metabol.2009.04.041
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发表时间：
2009-10
影响因子：
9.8
通讯作者：
Mohan, Vishwanathan
中科院分区：
文献类型：
--
作者：
Mathias, Rasika A.;Deepa, Mohan;Deepa, Raj;Wilson, Alexander F.;Mohan, Vishwanathan
印度是全球糖尿病公共卫生负担的主要贡献者。我们进行了一项来自印度南部钦奈的大型多重家族的家族研究，并报告了这些家系中与2型糖尿病相关的数量性状的家族聚集性。从26个大型多重家系中确定了524名19岁以上的个体。对所有参与者进行详细的问卷调查和表型数据，包括：空腹血糖、空腹胰岛素、血脂、身高、体重和其他人体测量和临床测量。在单变量水平上计算所有数量性状的遗传力估计值，并进行双变量分析以确定这些数量性状的遗传和环境控制的相关性。遗传力估计值范围为0.21至0.72。与2型糖尿病最直接相关的性状的遗传力估计值为：空腹血糖为0.24 ± 0.08，空腹胰岛素为0.41 ± 0.09。此外，有证据表明，许多对这些性状（分别为25对和45对）存在共同的遗传和环境控制。这些双变量分析表明，空腹胰岛素和中心性肥胖指标（BMI，腰围和臀围）有共同的基因，空腹胰岛素和腰围之间有完全的遗传相关性。与2型糖尿病相关的数量性状具有遗传性，提示某些家族或遗传效应。胰岛素和向心性肥胖相关性状的多效性控制的证据支持具有向心性肥胖倾向的南亚人存在胰岛素抵抗综合征。
India is a major contributor to the global public health burden of diabetes. We have undertaken a family study of large multiplex families from Chennai, South India and report on the familial aggregation of quantitative traits associated with Type 2 diabetes in these pedigrees. 524 individuals over the age of 19 from twenty-six large multiplex pedigrees were ascertained. Detailed questionnaires and phenotype data were obtained on all participating individuals including: fasting blood glucose, fasting insulin, lipid profiles, height, weight and other anthropometric and clinical measures. Heritability estimates were calculated for all quantitative traits at the univariate level, and bivariate analyses were done to determine the correlation in genetic and environmental control across these quantitative traits. Heritability estimates ranged from 0.21 to 0.72. The heritability estimates for traits most directly related to Type 2 diabetes were: 0.24 ± 0.08 for fasting blood glucose and 0.41 ± 0.09 for fasting insulin. In addition, there was evidence for common genetic and environmental control for many pairs of these traits (25 and 45 pairs, respectively). These bivariate analyses suggested common genes for fasting insulin and central obesity measures (BMI, waist and hip), with complete genetic correlation between fasting insulin and waist. Quantitative traits associated with Type 2 diabetes have heritabilities suggestive of some familial or genetic effect. The evidence for pleiotropic control of insulin and central obesity-related traits supports the presence of an insulin resistance syndrome in South Asians with a tendency for central obesity.
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影响因子：
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通讯作者：
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