The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.
The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.
复制标题
抑郁对自发性疼痛大鼠热伤害感受阈值的影响
DOI：
10.1007/s12264-010-0932-1
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发表时间：
2010-12
影响因子：
5.6
通讯作者：
Luo, Fei
中科院分区：
文献类型：
--
作者：
Su, Yuan-Lin;Wang, Ning;Gao, Ge;Wang, Jin-Yan;Luo, Fei
目的：近年来，人们对抑郁症和疼痛之间的相互作用越来越感兴趣。本研究的目的是研究抑郁症是否会导致自发性疼痛大鼠对有害刺激的敏感性降低。方法：采用嗅球切除大鼠作为抑郁模型。采用开阔场试验和体重变化评价抑郁样行为。将福尔马林溶液注射到大鼠后爪，产生持续的疼痛。在对侧注射福尔马林的后爪上施加有害热刺激，并测量戒断阈值。结果：在非抑郁大鼠中，福尔马林处理的足跖对有害刺激产生痛觉减退，而对侧足跖未受影响。然而，与非抑郁大鼠相比，抑郁大鼠对有害热刺激的敏感性明显降低，表现为对侧足部的戒断阈值较高。结论：这些结果表明，抑郁可以减轻刺激诱发的疼痛，即使是在福尔马林炎症性疼痛的情况下，这与先前的临床观察一致，即抑郁症和持续性疼痛患者对有害实验刺激的敏感性降低。
Objective:Recently, there has been growing interest in the interaction between depressive disorders and pain. The purpose of this study was to examine whether depression would lead to a decreased sensitivity to noxious stimuli in rats with spontaneous pain.Methods:The olfactory bulbectomized rats were used as a model of depression. The depression-like behaviors were assessed by open field test and changes in body weight. Formalin solution was injected into the rat hindpaw to produce ongoing pain. Noxious thermal stimuli were applied onto the hindpaw contralateral to formalin injection, and the withdrawal thresholds were measured.Results:In non-depressive rats, the formalin-treated paw developed hypoalgesia to noxious stimuli while the contralateral paw was not affected. The depressive rats, however, showed a significantly lower sensitivity to noxious thermal stimulus, represented as higher withdrawal thresholds of the contralateral paw, when compared to the non-depressive rats.Conclusion:These results demonstrate that depression can alleviate the stimulus-evoked pain even in the context of formalin inflammatory pain, consistent with the previous clinical observations that patients suffering from both depression and persistent pain have decreased sensitivities to noxious experimental stimuli.
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影响因子：
2.7
作者：
Mineur, Yann S.;Belzung, Catherine;Crusio, Wim E.
通讯作者：
Crusio, Wim E.
影响因子：
2
作者：
Biella, G;Bianchi, M;Sotgiu, ML
通讯作者：
Sotgiu, ML
影响因子：
2.9
作者：
Omote, K;Kawamata, T;Namiki, A
通讯作者：
Namiki, A
DOI：
10.1016/j.jpain.2009.07.002
发表时间：
2010-03
期刊：
The journal of pain
影响因子：
--
作者：
Shi M;Wang JY;Luo F
通讯作者：
Luo F
影响因子：
4.7
作者：
MERSKEY, H
通讯作者：
MERSKEY, H