Depression shows divergent effects on evoked and spontaneous pain behaviors in rats.
Depression shows divergent effects on evoked and spontaneous pain behaviors in rats.
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DOI：
10.1016/j.jpain.2009.07.002
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Luo F
中科院分区：
文献类型：
--
作者：
Shi M;Wang JY;Luo F
虽然抑郁和疼痛是常见的合并症，但它们的相互作用尚未完全了解。本研究旨在探讨抑郁对大鼠诱发痛行为（热痛和痛觉过敏）和自发痛行为（福尔马林痛）的影响。一个不可预测的慢性轻度应激（UCMS）的范式，以发展一个经典的抑郁症。采用蔗糖偏好实验、旷场实验和高架十字迷宫实验评价大鼠的情绪行为。结果表明，抑郁大鼠总是表现出更强的耐受伤害性热刺激下正常和完全弗氏佐剂（CFA）诱导的慢性疼痛条件下，相比非抑郁动物。有趣的是，与未暴露UCMS的大鼠相比，暴露于UCMS的大鼠由福尔马林注射诱导的自发伤害性行为显著增强。全身给予抗抑郁药氟西汀可使抑郁动物的伤害性行为恢复到正常水平。另一个发现是，炎症大鼠在没有暴露于UCMS的情况下倾向于表现出抑郁样行为。这些结果表明，抑郁对刺激诱发痛和自发痛有不同的影响，前者减轻，后者加重。视角：本研究提供的证据表明，抑郁症可以刺激诱发和自发性疼痛的不同影响，证实大鼠暴露于慢性轻度应激往往表现出降低疼痛敏感性的实验刺激，但增加强度的持续疼痛。这可能有助于进一步了解临床抑郁症和慢性疼痛之间的复杂关系。
Although it has been accepted that depression and pain are common comorbidities, their interaction is not fully understood. The present study was aimed to investigate the effects of depression on both evoked pain behavior (thermal induced nociception and hyperalgesia) and spontaneous pain behavior (formalin pain) in rats. An unpredictable chronic mild stress (UCMS) paradigm was employed to develop a classical depression. The emotional behaviors were assessed by sucrose preference test, open field test, and elevated plus-maze test. The results showed that the depressed rats always exhibited stronger tolerance to noxious thermal stimulation under both normal and complete Freund’s adjuvant (CFA)-induced chronic pain conditions, when compared to non-depressed animals. Interestingly, the spontaneous nociceptive behaviors induced by formalin injection were significantly enhanced in rats exposed to UCMS in comparison to those without UCMS. Systemic administration of antidepressant fluoxetine significantly restored the nociceptive behaviors to normal level in depressed animals. An additional finding was that the inflammatory rats tended to display depressive-like behaviors without being exposed to UCMS. These results demonstrated that depression can have different effects on stimulus-evoked pain and spontaneous pain, with alleviation in the former while aggravation in the latter. Perspective: The present study provides evidence that depression can have divergent effects on stimulus-evoked and spontaneous pain by confirming that rats exposed to chronic mild stress tend to exhibit decreased pain sensitivity to experimental stimuli but increased intensity of ongoing pain. This may contribute to further understanding of the perplexing relationship between clinical depression and chronic pain.
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