Clinical manifestations of COVID-19 in the general population: systematic review.
Clinical manifestations of COVID-19 in the general population: systematic review.
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DOI：
10.1007/s00508-020-01760-4
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发表时间：
2021-04
影响因子：
2.6
通讯作者：
Freire de Souza CD
中科院分区：
文献类型：
--
作者：
da Rosa Mesquita R;Francelino Silva Junior LC;Santos Santana FM;Farias de Oliveira T;Campos Alcântara R;Monteiro Arnozo G;Rodrigues da Silva Filho E;Galdino Dos Santos AG;Oliveira da Cunha EJ;Salgueiro de Aquino SH;Freire de Souza CD
在普通人群中，COVID-19的临床表现各不相同。本研究旨在对新冠肺炎确诊患者的临床表现进行文献梳理。对文献进行了系统的回顾。在数据库中共发现了8070篇科学成果。184项研究符合初始纳入标准，共计114046例患者。在完成阅读后，32项没有报告临床表现的研究被排除在外。152份出版物最终包括来自至少23个国家的41409人，报告了26种不同的临床表现。总体患病率大于或等于25%的症状有发热（58.66%）、咳嗽（54.52%）、呼吸困难（30.82%）、不适（29.75%）、乏力（28.16%）、痰液/分泌物（25.33%）6项。神经系统症状（20.82%）、皮肤症状（20.45%）、厌食（20.26%）、肌痛（16.9%）、打喷嚏（14.71%）、喉咙痛（14.41%）、鼻炎（14.29%）、鸡皮疙瘩（13.49%）、头痛（12.17%）、胸痛（11.49%）和腹泻（9.59%）为常见症状。只有一项研究报告了皮肤病表现。最不常见的体征/症状是咯血（1.65%）。在100例以上的研究中，发热（57.93%）、咳嗽（54.21%）和呼吸困难（30.64%）是3个主要症状。皮肤病学表现不出现在主要症状中。确定COVID-19的所有临床表现对于早期诊断和采取预防措施至关重要。本文的在线版本（10.1007/s00508-020-01760-4）包含补充资料，仅供授权用户使用。
Clinical manifestations of COVID-19 are varied in the general population. This study aimed to systematize the literature regarding clinical manifestations of patients with confirmed COVID-19. A systematic review of the literature was conducted. A total of 8070 scientific productions were found in the databases. Among the studies, 184 met the initial inclusion criteria, with a total of 114,046 patients. After complete reading, 32 studies that did not report clinical manifestations were excluded. The 152 publications finally included a total of 41,409 individuals from at least 23 countries and 26 different clinical manifestations were reported. In percentage terms, 6 symptoms had a general prevalence greater than or equal to 25%, namely, fever (58.66%), cough (54.52%), dyspnea (30.82%), malaise (29.75%), fatigue (28.16%) and sputum/secretion (25.33%). Neurological symptoms (20.82%), dermatological manifestations (20.45%), anorexia (20.26%), myalgia (16.9%), sneezing (14.71%), sore throat (14.41%), rhinitis (14.29%), goosebumps (13.49%), headache (12.17%), chest pain (11.49%) and diarrhea (9.59%) were other common symptoms. Only one study reported dermatological manifestations. The least frequent sign/symptom was hemoptysis (1.65%). In studies with more than 100 patients, the 3 main symptoms were fever (57.93%), cough (54.21%), and dyspnea (30.64%). Dermatological manifestations do not appear among the main symptoms. The identification of all clinical manifestations of COVID-19 is essential for an early diagnosis and the adoption of preventive measures. The online version of this article (10.1007/s00508-020-01760-4) contains supplementary material, which is available to authorized users.
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影响因子：
3.9
作者：
Kinoshita R;Anzai A;Jung SM;Linton NM;Miyama T;Kobayashi T;Hayashi K;Suzuki A;Yang Y;Akhmetzhanov AR;Nishiura H
通讯作者：
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2.2
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通讯作者：
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影响因子：
2.6
作者：
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通讯作者：
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