Pre-pandemic cognitive function and COVID-19 mortality: prospective cohort study.
Pre-pandemic cognitive function and COVID-19 mortality: prospective cohort study.
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DOI：
10.1007/s10654-021-00743-7
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发表时间：
2021-05
影响因子：
13.6
通讯作者：
Gale CR
中科院分区：
文献类型：
--
作者：
Batty GD;Deary IJ;Gale CR
病前认知功能标准测试表现较差与下呼吸道感染死亡风险升高有关，但与冠状病毒 (COVID-19) 死亡率的联系尚未得到检验。英国生物银行的参与者在研究开始时（2006-10）年龄在 40 至 69 岁之间，他们接受了反应时间测试（信息处理速度的指标），并评估了他们的语言-数字推理能力。 2020 年 4 月 1 日至 9 月 23 日期间，有反应时间测试结果的 494,932 人（269,602 名女性）中有 388 例登记确认的死亡病例（138 名女性）归因于 COVID-19，而有口头数字推理数据的 180,198 人（97,794 名女性）亚组中有 125 例此类死亡（38 名女性）。在根据年龄、性别和种族进行调整的分析中，反应时间慢 1 个标准差与 COVID-19 死亡率较高相关（风险比；95% 置信区间：1.18；1.09，1.28），语言数字推理测试中的 1 个标准差劣势也是如此（1.32；1.09，1.59）。虽然在对包括社会经济地位和生活方式因素在内的其他协变量进行调整后，这些关系有所减弱，但大流行前认知功能的两个指标仍然与 COVID-19 死亡率相关。在线版本包含可在 10.1007/s10654-021-00743-7 获取的补充材料。
Poorer performance on standard tests of pre-morbid cognitive function is related to an elevated risk of death from lower respiratory tract infections but the link with coronavirus (COVID‑19) mortality is untested. Participants in UK Biobank, aged 40 to 69 years at study induction (2006–10), were administered a reaction time test, an indicator of information processing speed, and also had their verbal-numeric reasoning assessed. Between April 1st and September 23rd 2020 there were 388 registry-confirmed deaths (138 women) ascribed to COVID-19 in 494,932 individuals (269,602 women) with a reaction time test result, and 125 such deaths (38 women) in the subgroup of 180,198 people (97,794 women) with data on verbal-numeric reasoning. In analyses adjusted for age, sex, and ethnicity, a one standard deviation slower reaction time was related to a higher rate of death from COVID-19 (hazard ratio; 95% confidence interval: 1.18; 1.09, 1.28), as was a one standard deviation disadvantage on the verbal-numeric reasoning test (1.32; 1.09, 1.59). While there was some attenuation in these relationships after adjustment for additional covariates which included socio-economic status and lifestyle factors, the two pre-pandemic indicators of cognitive function continued to be related to COVID-19 mortality. The online version contains supplementary material available at 10.1007/s10654-021-00743-7.
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