The Agewell trial: a pilot randomised controlled trial of a behaviour change intervention to promote healthy ageing and reduce risk of dementia in later life.
The Agewell trial: a pilot randomised controlled trial of a behaviour change intervention to promote healthy ageing and reduce risk of dementia in later life.
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DOI：
10.1186/s12888-015-0402-4
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发表时间：
2015-02-19
期刊：
影响因子：
4.4
通讯作者：
Whitaker CJ
中科院分区：
文献类型：
--
作者：
Clare L;Nelis SM;Jones IR;Hindle JV;Thom JM;Nixon JA;Cooney J;Jones CL;Tudor Edwards R;Whitaker CJ
生活方式因素是行为改变干预措施的主要目标，旨在促进健康老龄化和减少痴呆症风险。我们评估了一项目标设定干预措施，旨在促进认知和身体活动的增加，改善身心健康、饮食和健康。这是一项试点随机对照试验，旨在指导更大规模调查的规划，提供有关疗效的初步证据，并探讨可行性和可接受性。主要结果是参与身体和认知活动。50岁以上独立生活在社区的参与者是通过社区老年康复中心招募的。基线评估后，参与者被随机分配到以下三种情况之一：对照组（IC）接受采访，讨论有关活动和健康的信息；目标设定（GS n = 24）接受了一次访谈，在访谈中，他们设定了与身体、认知和社会活动、健康和营养有关的行为改变目标；有指导的目标设定组（GM, n = 24）进行目标设定访谈，然后每两个月进行一次电话指导。参与者和研究人员对小组分配不知情。12个月后对参与者进行重新评估。75名受试者被随机分组（中老年27例，老年24例，老年24例）。在12个月的随访中，两个目标设定组（GS n = 21, GM n = 22），相对于对照组（IC n = 27），他们的身体活动水平（效应值0.37）和认知活动水平（效应值0.15）都有所提高。在次要结局中，与对照组相比，两个目标设定组在记忆、执行功能、胆固醇水平、有氧能力、柔韧性、平衡、握力和敏捷性方面获得了额外的好处（效应值≥0.2）。与单独设定目标相比，增加后续指导在身体活动、身体组成、整体认知和记忆方面产生了进一步的益处（效应值≥0.2），但在其他领域则没有。发现招募程序、评估和干预的实施是可行的，所采取的方法是参与者可以接受的，没有不良影响。一个简短的、低成本的目标设定干预是可行和可接受的，并且有可能实现更多的活动参与。当前对照试验ISRCTN30080637
Lifestyle factors represent prime targets for behaviour change interventions to promote healthy ageing and reduce dementia risk. We evaluated a goal-setting intervention aimed at promoting increased cognitive and physical activity and improving mental and physical fitness, diet and health. This was a pilot randomised controlled trial designed to guide planning for a larger-scale investigation, provide preliminary evidence regarding efficacy, and explore feasibility and acceptability. Primary outcomes were engagement in physical and cognitive activity. Participants aged over 50 living independently in the community were recruited through a community Agewell Centre. Following baseline assessment participants were randomly allocated to one of three conditions: control (IC) had an interview in which information about activities and health was discussed; goal-setting (GS n = 24) had an interview in which they set behaviour change goals relating to physical, cognitive and social activity, health and nutrition; and goal-setting with mentoring (GM, n = 24) had the goal-setting interview followed by bi-monthly telephone mentoring. Participants and researchers were blinded to group assignment. Participants were reassessed after 12 months. Seventy-five participants were randomised (IC n = 27, GS n = 24, GM n = 24). At 12-month follow-up, the two goal-setting groups, taken together (GS n = 21, GM n = 22), increased their level of physical (effect size 0.37) and cognitive (effect size 0.15) activity relative to controls (IC n = 27). In secondary outcomes, the two goal-setting groups taken together achieved additional benefits compared to control (effect sizes ≥ 0.2) in memory, executive function, cholesterol level, aerobic capacity, flexibility, balance, grip strength, and agility. Adding follow-up mentoring produced further benefits compared to goal-setting alone (effect sizes ≥ 0.2) in physical activity, body composition, global cognition and memory, but not in other domains. Implementation of the recruitment procedure, assessment and intervention was found to be feasible and the approach taken was acceptable to participants, with no adverse effects. A brief, low-cost goal-setting intervention is feasible and acceptable, and has the potential to achieve increased activity engagement. Current Controlled Trials ISRCTN30080637
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影响因子：
120.7
作者：
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3.3
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