Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair.
Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repair.
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甲状旁腺激素相关蛋白对软骨细胞肥大的抑制作用：对关节软骨修复的意义
DOI：
10.1186/ar4025
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发表时间：
2012-08-31
影响因子：
4.9
通讯作者：
Ouyang HW
中科院分区：
文献类型：
--
作者：
Zhang W;Chen J;Zhang S;Ouyang HW
软骨修复组织通常伴随着软骨细胞肥大和骨过度生长，甲状旁腺激素相关蛋白（PTHrP）在软骨内成骨过程中抑制软骨细胞增生分化的作用已被证实。然而，PTHrP在软骨修复中的应用尚未得到广泛的考虑。本文首次系统综述了PTHrP对关节软骨软骨细胞肥大和软骨内成骨过程以及间充质干细胞成软骨分化过程的抑制作用。在文献综述的基础上，提出应用PTHrP进行关节软骨修复的策略，对软骨损伤及骨关节炎的临床治疗具有指导意义。
Cartilage repair tissue is usually accompanied by chondrocyte hypertrophy and osseous overgrowths, and a role for parathyroid hormone-related protein (PTHrP) in inhibiting chondrocytes from hypertrophic differentiation during the process of endochondral ossification has been demonstrated. However, application of PTHrP in cartilage repair has not been extensively considered. This review systemically summarizes for the first time the inhibitory function of PTHrP on chondrocyte hypertrophy in articular cartilage and during the process of endochondral ossification, as well as the process of mesenchymal stem cell chondrogenic differentiation. Based on the literature review, the strategy of using PTHrP for articular cartilage repair is suggested, which is instructive for clinical treatment of cartilage injuries as well as osteoarthritis.
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影响因子：
11.8
作者：
Correa, Diego;Hesse, Eric;Seriwatanachai, Dutmanee;Kiviranta, Riku;Saito, Hiroaki;Yamana, Kei;Neff, Lynn;Atfi, Azeddine;Coillard, Lucie;Sitara, Despina;Maeda, Yukiko;Warming, Soren;Jenkins, Nancy A.;Copeland, Neal G.;Horne, William C.;Lanske, Beate;Baron, Roland
通讯作者：
Baron, Roland
影响因子：
7
作者：
Kreuz, P. C.;Steinwachs, M. R.;Suedkamp, N.
通讯作者：
Suedkamp, N.
影响因子：
--
作者：
Chen, Xuesong;Macica, Carolyn M.;Nasiri, Ali;Broadus, Arthur E.
通讯作者：
Broadus, Arthur E.
Bcl-2位于甲状旁腺激素相关肽的下游信号传导途径中，该途径在骨骼发育过程中调节软骨细胞的成熟。
影响因子：
7.8
作者：
Amling, M;Neff, L;Tanaka, S;Inoue, D;Kuida, K;Weir, E;Philbrick, WM;Broadus, AE;Baron, R
通讯作者：
Baron, R
影响因子：
4.8
作者：
FUJIMORI, A;CHENG, SL;CIVITELLI, R
通讯作者：
CIVITELLI, R