Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.
Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.
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DOI：
10.1038/s41380-022-01897-w
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发表时间：
2023-03
影响因子：
11
通讯作者：
Walton, Esther
中科院分区：
文献类型：
--
作者：
Constantinides, Constantinos;Han, Laura K. M.;Alloza, Clara;Antonucci, Linda Antonella;Arango, Celso;Ayesa-Arriola, Rosa;Banaj, Nerisa;Bertolino, Alessandro;Borgwardt, Stefan;Bruggemann, Jason;Bustillo, Juan;Bykhovski, Oleg;Calhoun, Vince;Carr, Vaughan;Catts, Stanley;Chung, Young-Chul;Crespo-Facorro, Benedicto;Diaz-Caneja, Covadonga M.;Donohoe, Gary;Du Plessis, Stefan;Edmond, Jesse;Ehrlich, Stefan;Emsley, Robin;Eyler, Lisa T.;Fuentes-Claramonte, Paola;Georgiadis, Foivos;Green, Melissa;Guerrero-Pedraza, Amalia;Ha, Minji;Hahn, Tim;Henskens, Frans A.;Holleran, Laurena;Homan, Stephanie;Homan, Philipp;Jahanshad, Neda;Janssen, Joost;Ji, Ellen;Kaiser, Stefan;Kaleda, Vasily;Kim, Minah;Kim, Woo-Sung;Kirschner, Matthias;Kochunov, Peter;Kwak, Yoo Bin;Kwon, Jun Soo;Lebedeva, Irina;Liu, Jingyu;Mitchie, Patricia;Michielse, Stijn;Mothersill, David;Mowry, Bryan;de la Foz, Victor Ortiz-Garcia;Pantelis, Christos;Pergola, Giulio;Piras, Fabrizio;Pomarol-Clotet, Edith;Preda, Adrian;Quide, Yann;Rasser, Paul E.;Rootes-Murdy, Kelly;Salvador, Raymond;Sangiuliano, Marina;Sarro, Salvador;Schall, Ulrich;Schmidt, Andre;Scott, Rodney J.;Selvaggi, Pierluigi;Sim, Kang;Skoch, Antonin;Spalletta, Gianfranco;Spaniel, Filip;Thomopoulos, Sophia, I;Tomecek, David;Tomyshev, Alexander S.;Tordesillas-Gutierrez, Diana;van Amelsvoort, Therese;Vazquez-Bourgon, Javier;Vecchio, Daniela;Voineskos, Aristotle;Weickert, Cynthia S.;Weickert, Thomas;Thompson, Paul M.;Schmaal, Lianne;van Erp, Theo G. M.;Turner, Jessica;Cole, James H.;Dima, Danai;Walton, Esther
精神分裂症（SZ）与终身认知障碍、年龄相关慢性疾病和过早死亡的风险增加有关。我们调查了成年SZ患者的晚期脑老化的证据，以及这是否与ENIGMA精神分裂症工作组进行的前瞻性荟萃分析研究的临床特征相关。该研究包括来自全球26个队列的数据，共有2803例SZ患者（平均年龄34.2岁;范围18-72岁; 67%为男性）和2598例健康对照（平均年龄33.8岁，范围18-73岁，55%为男性）。使用基于68项皮质厚度和表面积、7项皮质下体积、侧脑室体积和总颅内体积的测量值的独立数据训练的模型单独估计大脑预测年龄，所有测量值均来自T1加权脑磁共振成像（MRI）扫描。通过脑预测年龄和实际年龄之间的差异（脑预测年龄差异[脑-PAD]）评估与健康脑老化轨迹的偏差。在调整年龄、性别和部位后，SZ患者的平均脑PAD比对照组高3.55岁（95% CI：2.91，4.19; I2 = 57.53%）（Cohen d = 0.48）。在SZ患者中，脑PAD与特定的临床特征（发病年龄、病程、症状严重程度或抗精神病药物的使用和剂量）无关。这项大规模的合作研究表明，深圳的大脑结构老化程度很高。SZ的纵向研究和一系列的精神和躯体健康结果将有助于进一步评估脑PAD增加的临床意义及其受干预措施影响的能力。
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18–72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18–73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen’s d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
4.8
作者：
Beck D;de Lange AG;Pedersen ML;Alnaes D;Maximov II;Voldsbekk I;Richard G;Sanders AM;Ulrichsen KM;Dørum ES;Kolskår KK;Høgestøl EA;Steen NE;Djurovic S;Andreassen OA;Nordvik JE;Kaufmann T;Westlye LT
通讯作者：
Westlye LT
影响因子：
6.6
作者：
Koutsouleris, Nikolaos;Davatzikos, Christos;Meisenzahl, Eva
通讯作者：
Meisenzahl, Eva
影响因子：
11
作者：
Kelly S;Jahanshad N;Zalesky A;Kochunov P;Agartz I;Alloza C;Andreassen OA;Arango C;Banaj N;Bouix S;Bousman CA;Brouwer RM;Bruggemann J;Bustillo J;Cahn W;Calhoun V;Cannon D;Carr V;Catts S;Chen J;Chen JX;Chen X;Chiapponi C;Cho KK;Ciullo V;Corvin AS;Crespo-Facorro B;Cropley V;De Rossi P;Diaz-Caneja CM;Dickie EW;Ehrlich S;Fan FM;Faskowitz J;Fatouros-Bergman H;Flyckt L;Ford JM;Fouche JP;Fukunaga M;Gill M;Glahn DC;Gollub R;Goudzwaard ED;Guo H;Gur RE;Gur RC;Gurholt TP;Hashimoto R;Hatton SN;Henskens FA;Hibar DP;Hickie IB;Hong LE;Horacek J;Howells FM;Hulshoff Pol HE;Hyde CL;Isaev D;Jablensky A;Jansen PR;Janssen J;Jönsson EG;Jung LA;Kahn RS;Kikinis Z;Liu K;Klauser P;Knöchel C;Kubicki M;Lagopoulos J;Langen C;Lawrie S;Lenroot RK;Lim KO;Lopez-Jaramillo C;Lyall A;Magnotta V;Mandl RCW;Mathalon DH;McCarley RW;McCarthy-Jones S;McDonald C;McEwen S;McIntosh A;Melicher T;Mesholam-Gately RI;Michie PT;Mowry B;Mueller BA;Newell DT;O'Donnell P;Oertel-Knöchel V;Oestreich L;Paciga SA;Pantelis C;Pasternak O;Pearlson G;Pellicano GR;Pereira A;Pineda Zapata J;Piras F;Potkin SG;Preda A;Rasser PE;Roalf DR;Roiz R;Roos A;Rotenberg D;Satterthwaite TD;Savadjiev P;Schall U;Scott RJ;Seal ML;Seidman LJ;Shannon Weickert C;Whelan CD;Shenton ME;Kwon JS;Spalletta G;Spaniel F;Sprooten E;Stäblein M;Stein DJ;Sundram S;Tan Y;Tan S;Tang S;Temmingh HS;Westlye LT;Tønnesen S;Tordesillas-Gutierrez D;Doan NT;Vaidya J;van Haren NEM;Vargas CD;Vecchio D;Velakoulis D;Voineskos A;Voyvodic JQ;Wang Z;Wan P;Wei D;Weickert TW;Whalley H;White T;Whitford TJ;Wojcik JD;Xiang H;Xie Z;Yamamori H;Yang F;Yao N;Zhang G;Zhao J;van Erp TGM;Turner J;Thompson PM;Donohoe G
通讯作者：
Donohoe G
影响因子：
4.8
作者：
Franke K;Gaser C;Manor B;Novak V
通讯作者：
Novak V