Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.
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DOI：
10.1038/mp.2017.170
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发表时间：
2018-05
影响因子：
11
通讯作者：
Donohoe G
中科院分区：
文献类型：
--
作者：
Kelly S;Jahanshad N;Zalesky A;Kochunov P;Agartz I;Alloza C;Andreassen OA;Arango C;Banaj N;Bouix S;Bousman CA;Brouwer RM;Bruggemann J;Bustillo J;Cahn W;Calhoun V;Cannon D;Carr V;Catts S;Chen J;Chen JX;Chen X;Chiapponi C;Cho KK;Ciullo V;Corvin AS;Crespo-Facorro B;Cropley V;De Rossi P;Diaz-Caneja CM;Dickie EW;Ehrlich S;Fan FM;Faskowitz J;Fatouros-Bergman H;Flyckt L;Ford JM;Fouche JP;Fukunaga M;Gill M;Glahn DC;Gollub R;Goudzwaard ED;Guo H;Gur RE;Gur RC;Gurholt TP;Hashimoto R;Hatton SN;Henskens FA;Hibar DP;Hickie IB;Hong LE;Horacek J;Howells FM;Hulshoff Pol HE;Hyde CL;Isaev D;Jablensky A;Jansen PR;Janssen J;Jönsson EG;Jung LA;Kahn RS;Kikinis Z;Liu K;Klauser P;Knöchel C;Kubicki M;Lagopoulos J;Langen C;Lawrie S;Lenroot RK;Lim KO;Lopez-Jaramillo C;Lyall A;Magnotta V;Mandl RCW;Mathalon DH;McCarley RW;McCarthy-Jones S;McDonald C;McEwen S;McIntosh A;Melicher T;Mesholam-Gately RI;Michie PT;Mowry B;Mueller BA;Newell DT;O'Donnell P;Oertel-Knöchel V;Oestreich L;Paciga SA;Pantelis C;Pasternak O;Pearlson G;Pellicano GR;Pereira A;Pineda Zapata J;Piras F;Potkin SG;Preda A;Rasser PE;Roalf DR;Roiz R;Roos A;Rotenberg D;Satterthwaite TD;Savadjiev P;Schall U;Scott RJ;Seal ML;Seidman LJ;Shannon Weickert C;Whelan CD;Shenton ME;Kwon JS;Spalletta G;Spaniel F;Sprooten E;Stäblein M;Stein DJ;Sundram S;Tan Y;Tan S;Tang S;Temmingh HS;Westlye LT;Tønnesen S;Tordesillas-Gutierrez D;Doan NT;Vaidya J;van Haren NEM;Vargas CD;Vecchio D;Velakoulis D;Voineskos A;Voyvodic JQ;Wang Z;Wan P;Wei D;Weickert TW;Whalley H;White T;Whitford TJ;Wojcik JD;Xiang H;Xie Z;Yamamori H;Yang F;Yao N;Zhang G;Zhao J;van Erp TGM;Turner J;Thompson PM;Donohoe G
精神分裂症中白质（WM）异常的区域分布仍然知之甚少，不同研究之间报道的疾病对大脑的影响差异很大。为了努力确定研究的共性，我们进行了我们认为是有史以来第一次大规模的精神分裂症WM微观结构差异的协调研究。我们的分析包括来自29项独立国际研究的2359名健康对照者和1963名精神分裂症患者；我们统一了不同地点的扩散张量成像（DTI）数据的处理和统计分析，以及不同研究的meta分析效果。在精神分裂症患者中，分数各向异性（FA）的显著减少是普遍存在的，在WM骨骼中25个感兴趣的区域中有20个区域检测到FA，代表了所有主要的WM束。效应大小因区域而异，整个WM骨架的峰值为（d=0.42），更多地由外围区域驱动，而不是由核心WM驱动，核心WM定义了感兴趣的区域。前辐射冠（d=0.40）和胼胝体（d=0.39），尤其是胼胝体（d=0.39）和膝（d=0.37）的影响最大。几乎所有被分析的地区都观察到明显的下降，但程度较轻。FA的效应值大于扩散系数；与对照组相比，精神分裂症患者的平均弥漫性和径向弥漫性明显更高。没有发现精神分裂症发病年龄或药物剂量的显著影响。作为迄今为止对精神疾病中WM差异的最大规模的协调分析，本研究提供了世界范围内精神分裂症患者中广泛存在的WM异常的强有力的概况。结果的交互式三维可视化可在www.enigma-viewer.org上获得。
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
5.7
作者：
Jahanshad, Neda;Kochunov, Peter V.;Sprooten, Emma;Mandl, Rene C.;Nichols, Thomas E.;Almasy, Laura;Blangero, John;Brouwer, Rachel M.;Curran, Joanne E.;de Zubicaray, Greig I.;Duggirala, Ravi;Fox, Peter T.;Hong, L. Elliot;Landman, Bennett A.;Martin, Nicholas G.;McMahon, Katie L.;Medland, Sarah E.;Mitchell, Braxton D.;Olvera, Rene L.;Peterson, Charles P.;Starr, John M.;Sussmann, Jessika E.;Toga, Arthur W.;Wardlaw, Joanna M.;Wright, Margaret J.;Pol, Hilleke E. Hulshoff;Bastin, Mark E.;McIntosh, Andrew M.;Deary, Ian J.;Thompson, Paul M.;Glahn, David C.
通讯作者：
Glahn, David C.
影响因子：
10.6
作者：
Highley, JR;Esiri, MM;Crow, TJ
通讯作者：
Crow, TJ
影响因子：
5.7
作者：
Bach, Michael;Laun, Frederik B.;Maier-Hein, Klaus H.
通讯作者：
Maier-Hein, Klaus H.
影响因子：
5.4
作者：
Cassoli JS;Guest PC;Malchow B;Schmitt A;Falkai P;Martins-de-Souza D
通讯作者：
Martins-de-Souza D