Informatics and standards for nanomedicine technology.
Informatics and standards for nanomedicine technology.
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DOI：
10.1002/wnan.152
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发表时间：
2011-09
影响因子：
8.6
通讯作者：
Baker, Nathan A.
中科院分区：
文献类型：
--
作者：
Thomas, Dennis G.;Klaessig, Fred;Harper, Stacey L.;Fritts, Martin;Hoover, Mark D.;Gaheen, Sharon;Stokes, Todd H.;Reznik-Zellen, Rebecca;Freund, Elaine T.;Klemm, Juli D.;Paik, David S.;Baker, Nathan A.
关于纳米技术研究和医学上的纳米技术研究产生的有关信息（或数据）的管理和有效使用（或数据）的问题有几个问题。这些数据的量很大，内容多样，并且在纳米材料的描述和表征中被差距和歧义所困扰。在这项工作中，我们回顾了纳米医学信息学的三个领域：信息资源；分类法，受控词汇和本体论；和信息标准。这些领域中每个领域中的信息学方法和标准对于实现数据的协作，数据共享，明确的表示和解释，语义（有意义的）搜索和数据集成至关重要；并确保数据质量，可靠性和可重复性。特别是，我们考虑了本综述中的四种类型的信息标准，即标准表征协议，通用术语标准，最低信息标准和标准数据通信（Exchange）格式。目前，由于数据中的差距和歧义，也很难应用计算方法和机器学习技术来分析，解释和识别高维本质上高维的数据的模式，并且也将纳米材料特性的变化与变化与变化它们的化学组成，合成，表征协议等。使用信息学方法和标准在本综述中讨论的纳米医学中的信息管理问题取得了进步对于纳米医学信息学的快速增长领域至关重要。
There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In this work, we have reviewed three areas of nanomedicine informatics: information resources; taxonomies, controlled vocabularies, and ontologies; and information standards. Informatics methods and standards in each of these areas are critical for enabling collaboration, data sharing, unambiguous representation and interpretation of data, semantic (meaningful) search and integration of data; and for ensuring data quality, reliability, and reproducibility. In particular, we have considered four types of information standards in this review, which are standard characterization protocols, common terminology standards, minimum information standards, and standard data communication (exchange) formats. Currently, due to gaps and ambiguities in the data, it is also difficult to apply computational methods and machine learning techniques to analyze, interpret and recognize patterns in data that are high dimensional in nature, and also to relate variations in nanomaterial properties to variations in their chemical composition, synthesis, characterization protocols, etc. Progress towards resolving the issues of information management in nanomedicine using informatics methods and standards discussed in this review will be essential to the rapidly growing field of nanomedicine informatics.
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