Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS).
Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS).
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DOI：
10.3390/ijerph15091880
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发表时间：
2018-08-30
影响因子：
--
通讯作者：
Weihe P
中科院分区：
文献类型：
--
作者：
Petersen MS;Halling J;Jørgensen N;Nielsen F;Grandjean P;Jensen TK;Weihe P
精液质量可能会受到环境化学品的不利影响，如多氯联苯（PCB）和全氟烷基化物（PFAS），这些化学品具有持久性，可能会干扰内分泌。本研究的目的是探讨多氯联苯或PFAS暴露是否与法罗群岛男性的精液质量或生殖激素异常有关。这项基于人群的横断面研究包括263名法罗群岛男性（24-26岁），他们提供了精液样本，用于评估精子浓度、精子总数、精液体积、形态和活力。抽取血液样本并分析生殖激素、多氯联苯和全氟辛烷磺酸。暴露于∑PCBs和全氟辛烷磺酸（PFOS）与性激素结合球蛋白（SHBG）和黄体生成素（LH）呈正相关。此外，总睾酮（T）与∑PCB呈正相关。多氯联苯和全氟辛烷磺酸似乎都导致性激素结合球蛋白增加，可能是通过肝脏介导的。与PCB相关的较高的总T可能代表对升高的SHBG水平的补偿性适应，以维持不变的游离睾酮浓度。多氯联苯和全氟辛烷磺酸与LH的正相关性可能表明对产生睾丸激素的Leydig细胞产生了直接的不利影响。
Semen quality may be adversely affected by exposure to environmental chemicals such as polychlorinated biphenyls (PCBs) and perfluorinated alkylate substances (PFASs) that are persistent and may act as endocrine disrupting compounds. The aim of this study was to explore whether PCBs or PFASs exposure were associated with abnormalities in semen quality or reproductive hormones in Faroese men. This population based cross-sectional study includes 263 Faroese men (24–26 years) who delivered a semen sample for assessment of sperm concentration, total sperm count, semen volume, morphology and motility. A blood sample was drawn and analyzed for reproductive hormones, PCBs and PFASs. Exposure to ∑PCBs and perfluorooctane sulfonate (PFOS) was positively associated with sex hormone-binding globulin (SHBG) and luteinizing hormone (LH). In addition, total testosterone (T) was positively associated with ∑PCB. Both PCBs and PFOS appear to lead to increased SHBG, perhaps mediated via the liver. The higher total T associated with PCB may represent a compensatory adaption to elevated SHBG levels to maintain an unchanged free testosterone concentration. The positive association to LH for both PCBs and PFOS may indicate a direct adverse effect on the testosterone producing Leydig cells.
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DOI：
10.1016/j.reprotox.2012.07.005
发表时间：
2012-12
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Grandjean P;Grønlund C;Kjær IM;Jensen TK;Sørensen N;Andersson AM;Juul A;Skakkebæk NE;Budtz-Jørgensen E;Weihe P
通讯作者：
Weihe P
影响因子：
15.8
作者：
Heilmann C;Grandjean P;Weihe P;Nielsen F;Budtz-Jørgensen E
通讯作者：
Budtz-Jørgensen E
影响因子：
--
作者：
Cook, M. B.;Trabert, B.;McGlynn, K. A.
通讯作者：
McGlynn, K. A.
影响因子：
2.6
作者：
Kim, IS;Ariyaratne, HBS;Mendis-Handagama, SMLC
通讯作者：
Mendis-Handagama, SMLC
影响因子：
--
作者：
Jorgensen, N;Auger, J;Skakkebaek, NE
通讯作者：
Skakkebaek, NE