Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.
Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.
复制标题
磁共振成像测量脑血管反应性的系统评价。
DOI：
10.3389/fphys.2021.643468
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发表时间：
2021
影响因子：
4
通讯作者：
Thrippleton MJ
中科院分区：
文献类型：
--
作者：
Sleight E;Stringer MS;Marshall I;Wardlaw JM;Thrippleton MJ
脑血管反应性(CVR)磁共振成像(MRI)探测对血管扩张刺激反应的脑血流动力学变化。CVR与血管系统的健康密切相关，因此是研究中风、小血管疾病和痴呆等脑血管疾病的关键参数。MRI允许活体测量CVR，但文献中提出了几种不同的方法，在脉冲序列、硬件要求、刺激和图像处理技术方面存在差异。我们系统地回顾了截至2020年6月使用MRI测量CVR的出版物，确定了235篇相关文章。我们总结了采集方法、实验参数、所使用的硬件和CVR量化方法、调查的临床人群，以及相应的CVR措施总结。CVR在许多病理中被研究，如狭窄闭塞疾病、痴呆和小血管疾病，患者的CVR通常低于健康对照组。采用固定吸入二氧化碳气体或呼气末二氧化碳强制刺激的血氧水平依赖(BOLD)采集是最常用的方法。以呼气末二氧化碳为回归变量对MRI信号进行一般线性建模是计算CVR最常用的方法。我们对CVR测量方法和应用的调查将帮助研究人员确定良好的实践，并提供客观信息，为未来共识建议的制定提供信息。
Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the health of the vasculature and is therefore a key parameter for studying cerebrovascular diseases such as stroke, small vessel disease and dementias. MRI allows in vivo measurement of CVR but several different methods have been presented in the literature, differing in pulse sequence, hardware requirements, stimulus and image processing technique. We systematically reviewed publications measuring CVR using MRI up to June 2020, identifying 235 relevant papers. We summarised the acquisition methods, experimental parameters, hardware and CVR quantification approaches used, clinical populations investigated, and corresponding summary CVR measures. CVR was investigated in many pathologies such as steno-occlusive diseases, dementia and small vessel disease and is generally lower in patients than in healthy controls. Blood oxygen level dependent (BOLD) acquisitions with fixed inspired CO2 gas or end-tidal CO2 forcing stimulus are the most commonly used methods. General linear modelling of the MRI signal with end-tidal CO2 as the regressor is the most frequently used method to compute CVR. Our survey of CVR measurement approaches and applications will help researchers to identify good practice and provide objective information to inform the development of future consensus recommendations.
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影响因子：
3.3
作者：
Blockley, Nicholas P.;Driver, Ian D.;Gowland, Penny A.
通讯作者：
Gowland, Penny A.
影响因子：
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通讯作者：
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影响因子：
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作者：
Champagne, Allen A.;Coverdale, Nicole S.;Cook, Douglas J.
通讯作者：
Cook, Douglas J.