Breast Implant-Associated Immunological Disorders.
Breast Implant-Associated Immunological Disorders.
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DOI：
10.1155/2022/8536149
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发表时间：
2022
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
乳房通常放置在乳腺癌后的重建，化妆品的增强和性别疗法的手术（BII）是与乳房侵害的全身并发症。表征BII自身免疫性疾病并确定其病因的可能原因。
PubMed，Google Scholar，Embase，Web of Science和OVID数据库从2010年到2020年进行了查询策略，包括“植入物”，“乳房植入物疾病”，“自身免疫性”和“全身性疾病”的搜索术语组合。
BII包括一系列自身免疫性症状，例如疲劳，肌痛/关节，眼睛/口干和皮疹。 OME减轻超过50％的患者的症状，加强将乳房与BII联系起来的假设表明，有机化是一种生物学上的惰性材料，并且不太可能导致这些症状的原因，这是因为在其他植入生物疗法的情况下，还可以增加自身免疫性疾病的风险。宿主 - 病原体相互作用是该问题的混杂因素。
BII可以依赖生物膜感染，并且必须进一步研究这些抱怨背后的真正病理生理学。
Breast implants are commonly placed postbreast cancer reconstruction, cosmetic augmentation, and gender-affirming surgery. Breast implant illness (BII) is a systemic complication associated with breast implants. Patients with BII may experience autoimmune symptoms including fatigue, difficulty concentrating, hair loss, weight change, and depression. BII is poorly understood, and the etiology is unknown. The purpose of this literature review is to characterize BII autoimmune disorders and determine possible causes for its etiology. The PubMed, Google Scholar, Embase, Web of Science, and OVID databases were interrogated from 2010 to 2020 using a query strategy including search term combinations of “implants,” “breast implant illness,” “autoimmune,” and “systemic illness.” BII includes a spectrum of autoimmune symptoms such as fatigue, myalgias/arthralgias, dry eyes/mouth, and rash. A review of epidemiological studies in the past ten years exhibited evidence affirming an association between breast implants and autoimmune diseases. The most commonly recognized were Sjogren's syndrome, rheumatoid arthritis, systemic sclerosis, chronic fatigue syndrome, and Raynaud's syndrome. Explantation resulted in alleviation of symptoms in over 50% of patients, strengthening the hypothesis linking breast implants to BII. Studies have shown that silicone is a biologically inert material and unlikely to be the cause of these symptoms. This is supported by the fact that increased risk of autoimmune disease was also reported in patients with other implantable biomaterials such as orthopedic implants. Recent studies shed light on a possible role of bacterial biofilm and subsequent host-pathogen interactions as a confounding factor to this problem. BII could be dependent on biofilm infection and the microenvironment around the implants. The true pathophysiology behind these complaints must be further investigated so that alternative treatment regimens other than explantation can be developed. Translational significance of these studies is not limited to breast implants but extends to other implants as well.
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影响因子：
4.4
作者：
de Boer M;Colaris M;van der Hulst RRWJ;Cohen Tervaert JW
通讯作者：
Cohen Tervaert JW
影响因子：
12.8
作者：
Halpert, Gilad;Watad, Abdulla;Shoenfeld, Yehuda
通讯作者：
Shoenfeld, Yehuda
影响因子：
3.3
作者：
Cohen, Jared A.;Ghobadi, Armin
通讯作者：
Ghobadi, Armin
影响因子：
3.6
作者：
Hölmich, LR;Kjoller, K;Friis, S
通讯作者：
Friis, S
影响因子：
3.4
作者：
CUELLAR, ML;GLUCK, O;ESPINOZA, R
通讯作者：
ESPINOZA, R