Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey.
Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey.
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与美国人口空腹血脂相关的遗传变异：第三次全国健康和营养检查调查。
DOI：
10.1186/1471-2350-11-62
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发表时间：
2010-04-20
影响因子：
--
通讯作者：
Dowling, Nicole F.
中科院分区：
文献类型：
--
作者：
Chang, Man-huei;Yesupriya, Ajay;Ned, Renee M.;Mueller, Patricia W.;Dowling, Nicole F.
在一项大型的、基于人群的、具有全国代表性的研究中识别与血脂水平相关的遗传变异，可能有助于更好地了解美国人口中主要种族/族裔群体对血脂水平的遗传贡献。利用第三次全国健康与营养调查（NHANES III）第二阶段（1991-1994）的数据，我们研究了13个候选基因的22个多态性与4种血脂（高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）和甘油三酯（TG））之间的关联。采用单变量和多变量线性回归和基因内单倍型趋势回归来检验遗传关联，假设美国三个主要种族/种族群体（非西班牙裔白色、非西班牙裔黑人和墨西哥裔美国人）的遗传模式为加性。在粗分析和校正分析中，发现APOE（rs7412，rs 429358），PON 1（rs 854560），ITGB 3（rs 5918）和NOS 3（rs 2070744）内的变异与至少一个种族/种族组的一种或多种血脂相关。在非西班牙裔白人中，没有个体多态性与任何脂质性状相关。而PON 1 A-G单倍型与LDL-C和TC显著相关。在非西班牙裔黑人中，APOE变体rs7412和单倍型T-T与LDL-C和TC密切相关;而ITGB 3的rs 5918与TG显著相关。在墨西哥裔美国人中，三个基因的几个变体和单倍型与血脂显著相关：PON 1与HDL-C相关; APOE和NOS 3与LDL-C相关; APOE与TC相关。我们报告了血脂与APOE，ITGB 3，NOS 3和PON 1的变异和单倍型在美国三个主要种族/民族人群中的显着关联使用一个大的，全国代表性和基于人群的抽样调查。我们的研究结果有助于越来越多的文献确定血浆脂蛋白浓度的关键决定因素，并可以提供深入了解血清脂质和胆固醇浓度的生物学机制。
The identification of genetic variants related to blood lipid levels within a large, population-based and nationally representative study might lead to a better understanding of the genetic contribution to serum lipid levels in the major race/ethnic groups in the U.S. population. Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). Variants within APOE (rs7412, rs429358), PON1 (rs854560), ITGB3 (rs5918), and NOS3 (rs2070744) were found to be associated with one or more blood lipids in at least one race/ethnic group in crude and adjusted analyses. In non-Hispanic whites, no individual polymorphisms were associated with any lipid trait. However, the PON1 A-G haplotype was significantly associated with LDL-C and TC. In non-Hispanic blacks, APOE variant rs7412 and haplotype T-T were strongly associated with LDL-C and TC; whereas, rs5918 of ITGB3 was significantly associated with TG. Several variants and haplotypes of three genes were significantly related to lipids in Mexican Americans: PON1 in relation to HDL-C; APOE and NOS3 in relation to LDL-C; and APOE in relation to TC. We report the significant associations of blood lipids with variants and haplotypes in APOE, ITGB3, NOS3, and PON1 in the three main race/ethnic groups in the U.S. population using a large, nationally representative and population-based sample survey. Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations.
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影响因子：
8.7
作者：
Carter, AM;Catto, AJ;Grant, PJ
通讯作者：
Grant, PJ
DOI：
10.1097/00008571-200401000-00007
发表时间：
2004-01-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Chen, S;Tsybouleva, N;Marian, AJ
通讯作者：
Marian, AJ
影响因子：
4.8
作者：
Chrysohoou, C;Panagiotakos, DB;Stefanadis, C
通讯作者：
Stefanadis, C
影响因子：
3.1
作者：
Dedoussis, George V. Z.;Theodoraki, Eirini V.;Zampelas, Antonis
通讯作者：
Zampelas, Antonis
DOI：
10.1089/gte.2006.10.192
发表时间：
2006-09-01
期刊：
GENETIC TESTING
影响因子：
--
作者：
Dedoussis, George V. Z.;Maumus, Sandy;Visvikis-Siest, Sophie
通讯作者：
Visvikis-Siest, Sophie