Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts.
Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts.
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DOI：
10.1016/j.brs.2020.07.002
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发表时间：
2020-09
影响因子：
7.7
通讯作者：
Bremner JD
中科院分区：
文献类型：
--
作者：
Wittbrodt MT;Gurel NZ;Nye JA;Ladd S;Shandhi MMH;Huang M;Shah AJ;Pearce BD;Alam ZS;Rapaport MH;Murrah N;Ko YA;Haffer AA;Shallenberger LH;Vaccarino V;Inan OT;Bremner JD
创伤性应激可能对神经生物学产生持久影响，并导致精神疾病，如创伤后应激障碍（PTSD）。我们假设，非侵入性颈部迷走神经刺激（nVNS）可以减轻创伤症状，减少应激交感神经反应。这项研究探讨了nVNS如何改变神经反应的个性化创伤脚本。19名经历过创伤但没有被诊断为PTSD的参与者完成了这项双盲假对照研究。在三个连续的时间块中，向参与者呈现个性化的创伤脚本，然后立即进行假刺激（n = 8; 0-14 V，0.2 Hz，脉宽= 5 s）或主动nVNS（n = 11; 0-30 V，25 Hz，脉宽= 40 ms）。使用高分辨率正电子发射断层扫描（HR-PET）和放射性标记水测量脑血流量来评估创伤脚本期间的脑活动。创伤性脚本导致双侧内侧和眶前额叶皮质、运动前皮质、前扣带回、丘脑、海马、右杏仁核和右壳核内的显著激活。与双侧前额叶和眶额皮质、运动前皮质、颞叶、海马旁回、海马回和左前扣带回内的nVNS相比，在假刺激期间观察到更大的激活。在第一次暴露于创伤脚本，更大的激活被发现在运动皮层和腹侧视觉流，而前额叶皮层和前扣带回激活更占主导地位，后来的脚本介绍那些受试者接受假刺激。nVNS降低了边缘系统和其他与压力有关的大脑区域对情绪压力源的神经反应，重复暴露的变化表明从场景评估到认知处理情绪事件的转变。
Traumatic stress can have lasting effects on neurobiology and result in psychiatric conditions such as posttraumatic stress disorder (PTSD). We hypothesize that non-invasive cervical vagal nerve stimulation (nVNS) may alleviate trauma symptoms by reducing stress sympathetic reactivity. This study examined how nVNS alters neural responses to personalized traumatic scripts. Nineteen participants who had experienced trauma but did not have the diagnosis of PTSD completed this double-blind sham-controlled study. In three sequential time blocks, personalized traumatic scripts were presented to participants immediately followed by either sham stimulation (n = 8; 0–14 V, 0.2 Hz, pulse width = 5s) or active nVNS (n = 11; 0–30 V, 25 Hz, pulse width = 40 ms). Brain activity during traumatic scripts was assessed using High Resolution Positron Emission Tomography (HR-PET) with radiolabeled water to measure brain blood flow. Traumatic scripts resulted in significant activations within the bilateral medial and orbital prefrontal cortex, premotor cortex, anterior cingulate, thalamus, insula, hippocampus, right amygdala, and right putamen. Greater activation was observed during sham stimulation compared to nVNS within the bilateral prefrontal and orbitofrontal cortex, premotor cortex, temporal lobe, parahippocampal gyrus, insula, and left anterior cingulate. During the first exposure to the trauma scripts, greater activations were found in the motor cortices and ventral visual stream whereas prefrontal cortex and anterior cingulate activations were more predominant with later script presentations for those subjects receiving sham stimulation. nVNS decreases neural reactivity to an emotional stressor in limbic and other brain areas involved in stress, with changes over repeated exposures suggesting a shift from scene appraisal to cognitively processing the emotional event.
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影响因子：
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Burger AM;Van Diest I;van der Does W;Hysaj M;Thayer JF;Brosschot JF;Verkuil B
通讯作者：
Verkuil B