Transcutaneous vagus nerve stimulation and extinction of prepared fear: A conceptual non-replication.
Transcutaneous vagus nerve stimulation and extinction of prepared fear: A conceptual non-replication.
复制标题
经皮神经刺激和制备恐惧的灭绝：一种概念性的非复制。
DOI：
10.1038/s41598-018-29561-w
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发表时间：
2018-07-31
影响因子：
4.6
通讯作者：
Verkuil B
中科院分区：
文献类型：
--
作者：
Burger AM;Van Diest I;van der Does W;Hysaj M;Thayer JF;Brosschot JF;Verkuil B
经皮刺激迷走神经耳支（tVNS）可能会加速健康人的恐惧消退。在这里，我们的目的是在准备好的学习范式中，使用蜘蛛图片作为条件刺激，在健康的年轻参与者中研究这一假设。在恐惧调节阶段后，参与者被随机分配在消退阶段接受 tVNS（最终 N = 42）或假刺激（最终 N = 43）。使用美国预期评级、皮肤电导和恐惧增强的惊吓反应来评估条件性恐惧。在成功获得恐惧后，两组参与者在灭绝阶段的过程中都表现出恐惧的减少。恐惧的生理指标的消退率没有组间差异。与之前的研究结果相反，tVNS 条件下的参与者也没有表现出加速的声明性灭绝学习。与接受假刺激的参与者相比，tVNS 条件下的参与者对 CS− 试验的初始美国预期评级确实较低，这可能表明 tVNS 导致的安全线索处理能力增强。总之，没有观察到由 tVNS 引起的预期加速灭绝。这项研究的结果要求对最佳 tVNS 刺激强度设置进行更多研究。
Transcutaneous stimulation of the auricular branch of the vagus nerve (tVNS) may accelerate fear extinction in healthy humans. Here, we aimed to investigate this hypothesis in healthy young participants in a prepared learning paradigm, using spider pictures as conditioned stimuli. After a fear conditioning phase, participants were randomly allocated to receive tVNS (final N = 42) or sham stimulation (final N = 43) during an extinction phase. Conditioned fear was assessed using US expectancy ratings, skin conductance and fear potentiated startle responses. After successful fear acquisition, participants in both groups showed a reduction of fear over the course of the extinction phase. There were no between-group differences in extinction rates for physiological indices of fear. Contrary to previous findings, participants in the tVNS condition also did not show accelerated declarative extinction learning. Participants in the tVNS condition did have lower initial US expectancy ratings for the CS− trials than those who received sham stimulation, which may indicate an enhanced processing of safety cues due to tVNS. In conclusion, the expected accelerated extinction due to tVNS was not observed. The results from this study call for more research on the optimal tVNS stimulation intensity settings.
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