Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications.
Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications.
复制标题
肝内胆管癌中的骨膜素：病理生物学见解和临床意义。
DOI：
10.1016/j.yexmp.2014.10.007
复制
发表时间：
2014-12
影响因子：
3.6
通讯作者：
Li, Chao
中科院分区：
文献类型：
--
作者：
Sirica, Alphonse E.;Almenara, Jorge A.;Li, Chao
关键词：
骨膜蛋白是一种模块化的糖蛋白，经常被观察到是形成团块的肝内胆管癌和其他结缔组织增生恶性肿瘤细胞外环境的主要成分。在肝内胆管癌和胰管间质结缔组织增生腺癌中，骨膜蛋白大部分（如果不是全部）是由肿瘤间质中与癌症相关的成纤维细胞过度表达和高分泌的。通过与细胞外肿瘤基质的特定成分，特别是I型胶原和tenascin-C，以及与细胞表面受体，特别是整合素的相互作用，激活Akt和FAK信号通路，这种TGF-β家族诱导的基质蛋白似乎是一个关键的细胞外基质分子，调节肿瘤纤维形成和结缔组织增生等至关重要和多样化的恶性肿瘤行为。侵袭性恶性细胞生长、化疗耐药和转移性定植。这篇综述将讨论目前的证据和基本的分子机制暗示骨膜蛋白作为肝内胆管癌侵袭性生长的介质。此外，将严格评估其作为肝内胆管癌患者潜在预后生物标志物的意义，以及作为胆管癌治疗和/或预防的分子靶点的未来可能性和挑战。
Periostin is a modular glycoprotein frequently observed to be a major constituent of the extracellular milieu of mass-forming intrahepatic cholangiocarcinoma and other desmoplastic malignant tumors. In intrahepatic cholangiocarcinoma, as well as in desmoplastic pancreatic ductal adenocarcinoma, periostin is overexpressed and hypersecreted in large part, if not exclusively, by cancer-associated fibroblasts within the tumor stroma. Through its interaction with specific components of the extracellular tumor matrix, particularly collagen type I and tenascin-C, and with cell surface receptors, notably integrins leading to activation of the Akt and FAK signaling pathways, this TGF-β family-inducible matricellular protein appears to be functioning as a key extracellular matrix molecule regulating such critically important and diverse malignant tumor behaviors as tumor fibrogenesis and desmoplasia, invasive malignant cell growth, chemoresistance, and metastatic colonization. This review will discuss current evidence and basic molecular mechanisms implicating periostin as a mediator of intrahepatic cholangiocarcinoma invasive growth. In addition, its significance as a potential prognostic biomarker for intrahepatic cholangiocarcinoma patients, as well as future possibilities and challenges as a molecular target for cholangiocarcinoma therapy and/or prevention, will be critically evaluated.
登录
查看更多内容
影响因子：
3.4
作者：
Hoersch S;Andrade-Navarro MA
通讯作者：
Andrade-Navarro MA
影响因子：
--
作者：
Darby, Ian A.;Vuillier-Devillers, Karine;Desmouliere, Alexis
通讯作者：
Desmouliere, Alexis
影响因子：
7.5
作者：
Fukushima, Noriyoshi;Kikuchi, Yoshinao;Fukayama, Masashi
通讯作者：
Fukayama, Masashi
影响因子：
3.6
作者：
Dumur, Catherine I.;Campbell, Deanna J. W.;Sirica, Alphonse E.
通讯作者：
Sirica, Alphonse E.
DOI：
10.1111/j.1872-034x.2012.01026.x
发表时间：
2012-11
期刊：
Hepatology research : the official journal of the Japan Society of Hepatology
影响因子：
--
作者：
Campbell DJ;Dumur CI;Lamour NF;Dewitt JL;Sirica AE
通讯作者：
Sirica AE