Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects.
Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects.
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DOI：
10.1002/mabi.202000379
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发表时间：
2021-04
影响因子：
4.6
通讯作者：
Chodosh J
中科院分区：
文献类型：
--
作者：
Sharifi S;Islam MM;Sharifi H;Islam R;Huq TN;Nilsson PH;Mollnes TE;Tran KD;Patzer C;Dohlman CH;Patra HK;Paschalis EI;Gonzalez-Andrades M;Chodosh J
电子束（E-beam）辐照是用于对由天然和/或合成材料（例如聚（甲基丙烯酸甲酯）（PMMA））制成的临床可植入医疗装置进行灭菌的有吸引力且有效的方法。由于电离辐射会影响PMMA的物理化学性质，因此了解电子束灭菌对PMMA内在性质的影响对于临床实施至关重要。详细评估了医用级PMMA在25和50 kGy电子束灭菌后的化学、光学、机械、形态和生物学特性。傅里叶变换红外光谱，热重分析，和差示扫描量热法的研究表明，电子束照射在这些剂量的PMMA的化学性质的影响最小。虽然25 kGy辐照不会改变PMMA的机械和光学性能，但50 kGy辐照会使弯曲强度和透明度分别降低10%和2%。原子力显微镜表明，电子束照射降低PMMA的表面粗糙度在剂量依赖的方式。Live-Dead、AlamarBlue、免疫细胞化学和补体激活研究表明，高达50 kGy的电子束辐照对PMMA的生物相容性没有不良影响。这些结果表明，25 kGy的电子束辐照可能是PMMA灭菌的一种安全有效的替代方法。
Electron beam (E-beam) irradiation is an attractive and efficient method for sterilizing clinically implantable medical devices made of natural and/or synthetic materials such as poly(methyl methacrylate) (PMMA). As ionizing irradiation can affect the physicochemical properties of PMMA, understanding the consequences of E-beam sterilization on the intrinsic properties of PMMA is vital for clinical implementation. A detailed assessment of the chemical, optical, mechanical, morphological, and biological properties of medical-grade PMMA after E-beam sterilization at 25 and 50 kiloGray (kGy) is reported. Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry studies indicate that E-beam irradiation has minimal effect on the chemical properties of the PMMA at these doses. While 25 kGy irradiation does not alter the mechanical and optical properties of the PMMA, 50 kGy reduces the flexural strength and transparency by 10% and 2%, respectively. Atomic force microscopy demonstrates that E-beam irradiation reduces the surface roughness of PMMA in a dose dependent manner. Live-Dead, AlamarBlue, immunocytochemistry, and complement activation studies show that E-beam irradiation up to 50 kGy has no adverse effect on the biocompatibility of the PMMA. These findings suggest that E-beam irradiation at 25 kGy may be a safe and efficient alternative for PMMA sterilization.
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影响因子：
2.8
作者：
ATCHISON, DA
通讯作者：
ATCHISON, DA
影响因子：
4.6
作者：
Sharifi S;Islam MM;Sharifi H;Islam R;Huq TN;Nilsson PH;Mollnes TE;Tran KD;Patzer C;Dohlman CH;Patra HK;Paschalis EI;Gonzalez-Andrades M;Chodosh J
通讯作者：
Chodosh J
影响因子：
2.8
作者：
Pujari, Siddharth;Siddique, Sana S.;Chodosh, James
通讯作者：
Chodosh, James
影响因子：
5.4
作者：
Sharifi, Roholah;Mahmoudzadeh, Soudabe;Gonzalez-Andrades, Miguel
通讯作者：
Gonzalez-Andrades, Miguel
影响因子：
--
作者：
LAZARE, S;SRINIVASAN, R
通讯作者：
SRINIVASAN, R