Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease.
Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease.
复制标题
血浆精氨酸酶-1水平与门诊慢性肝病患者心理状态的关系
DOI：
10.3390/diagnostics11020317
复制
发表时间：
2021-02-16
期刊：
影响因子：
--
通讯作者：
Ogino K
中科院分区：
文献类型：
--
作者：
Ogino N;Ikeda F;Namba S;Ohkubo S;Nishimura T;Okada H;Hirohata S;Suganuma N;Ogino K
虽然血浆谷胱甘肽酶-1已被认为是健康个体精神状态的生物标志物，但尚未在慢性肝病患者中进行评估。这项横断面研究调查了血浆谷胱甘肽酶-1筛查慢性肝病患者精神状态的效用。该研究包括2018年9月至2019年1月期间在冈山大学医院接受定期检查的慢性肝病门诊患者。除了标准的血液检查外，还分析了血浆谷胱甘肽酶-1水平。患者的精神状态使用一般健康问卷-28（GHQ-28）的日文版本进行评估。精神状态和各种参数之间的关联进行了调查，包括血浆辅酶Ⅰ酶-1，使用逻辑回归分析。在114名参与患者中，排除了8名患者，其中6名血液样本不足以进行血浆凝血酶-1测定，2名问卷不完整。多因素二项Logistic回归分析显示，血浆β-淀粉酶-1与GHQ总分呈显著负相关，尤其是躯体症状。因此，血浆β-淀粉酶-1可能是一个有用的生物标志物，用于评估慢性肝病门诊患者的精神状态。
While plasma arginase-1 has been suggested as a biomarker of mental status in healthy individuals, it has not been evaluated in patients with chronic liver disease. This cross-sectional study investigated the utility of plasma arginase-1 for screening mental status in patients with chronic liver disease. This study included outpatients with chronic liver disease who underwent regular check-ups at Okayama University Hospital between September 2018 and January 2019. In addition to the standard blood tests, the plasma arginase-1 level was analyzed. The patients’ mental status was assessed using the Japanese version of the General Health Questionnaire-28 (GHQ-28). The associations between mental status and various parameters, including plasma arginase-1, were investigated using logistic regression analysis. Among 114 participating patients, 8 were excluded, comprising 6 with insufficient blood samples for plasma arginase-1 measurement and 2 with incomplete questionnaires. Multivariate binomial logistic regression analysis revealed that plasma arginase-1 was significantly and negatively associated with the GHQ-total score, especially somatic symptoms. Therefore, plasma arginase-1 may be a useful biomarker for assessing the mental status of outpatients with chronic liver disease.
登录
查看更多内容
影响因子：
4.1
作者：
Lin YH;Jen MH;Chien KL
通讯作者：
Chien KL
影响因子：
7.4
作者：
Epel ES;Crosswell AD;Mayer SE;Prather AA;Slavich GM;Puterman E;Mendes WB
通讯作者：
Mendes WB
DOI：
10.1002/hep.29802
发表时间：
2019-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Church RJ;Kullak-Ublick GA;Aubrecht J;Bonkovsky HL;Chalasani N;Fontana RJ;Goepfert JC;Hackman F;King NMP;Kirby S;Kirby P;Marcinak J;Ormarsdottir S;Schomaker SJ;Schuppe-Koistinen I;Wolenski F;Arber N;Merz M;Sauer JM;Andrade RJ;van Bömmel F;Poynard T;Watkins PB
通讯作者：
Watkins PB
影响因子：
2.2
作者：
Liu, Cindy H.;Doan, Stacey N.
通讯作者：
Doan, Stacey N.
影响因子：
1.7
作者：
Dong，Ning;Chen，Wei-Ti;Lu，Hongzhou
通讯作者：
Lu，Hongzhou