Association between life-course socioeconomic position and inflammatory biomarkers in older age: a nationally representative cohort study in Taiwan.
Association between life-course socioeconomic position and inflammatory biomarkers in older age: a nationally representative cohort study in Taiwan.
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DOI：
10.1186/s12877-017-0598-x
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发表时间：
2017-09-02
期刊：
影响因子：
4.1
通讯作者：
Chien KL
中科院分区：
文献类型：
--
作者：
Lin YH;Jen MH;Chien KL
低社会经济地位 (SEP) 与炎症标志物之间关联的证据很少。本研究旨在探讨生命全程 SEP 如何预测全国队列中老年人的 C 反应蛋白 (CRP) 和白细胞介素 (IL-6)。我们收集了台湾社会环境和衰老生物标志物研究的 1036 名参与者的数据。回顾性测量了四个 SEP 时间点：童年、青年期、积极的职业生活和老年。采用基于群体的轨迹分析方法来识别生命全程 SEP 的不同轨迹，并将轨迹组成员身份用作老年 CRP 和 IL-6 水平的预测因子。在总样本中确定了生命全程 SEP 的三个轨迹：低-低 (36.5%)、低-高 (26.8%) 和高-高 (36.7%)。高-高组的参与者的 CRP 和 IL-6 水平最低。与低-低组相比，低-高组的参与者具有相似的调整后CRP [-0.032 ln mg/L； 95% 置信区间 (CI) − 0.193, 0.128] 和 IL-6（0.017 ln pg/mL；95% CI −0.093, 0.128）；高-高组的参与者调整后的 CRP 浓度水平显着较低（-0.279 ln mg/L；95% CI：-0.434，-0.125），IL-6 浓度也同样较低（-0.129 ln pg/mL；95% CI -0.236，-0.023）。生命全程SEP与老年时CRP和IL-6水平相关。我们的数据支持生命全程 SEP 预测老年炎症标志物的观点。儿童时期的低 SEP 与老年时期炎症标志物的升高有关。即使从儿童时期的低 SEP 转变为老年时的高 SEP，风险仍然存在。有必要进一步研究 SEP 和炎症相关疾病。
Evidence of an association between low socioeconomic position (SEP) and inflammatory markers is scant. This study aimed to examine how life-course SEP predicted C-reactive protein (CRP) and interleukin (IL-6) in older age from a national cohort. We collected data from 1036 participants in the Social Environment and Biomarkers of Aging Study in Taiwan. Four SEP time points, childhood, young adulthood, active professional life, and older age were measured retrospectively. A group-based trajectory analysis method was used to identify the distinct trajectories of life-course SEP, and trajectory group membership was used as the predictor of CRP and IL-6 levels in older age. Three trajectories of life-course SEP were identified within the total sample: Low-Low (36.5%), Low-High (26.8%), and High-High (36.7%). Participants in the High-High group had the lowest levels of CRP and IL-6. Compared with those in the Low-Low group, the participants in the Low-High group had a similar adjusted CRP [−0.032 ln mg/L; 95% confidence interval (CI) − 0.193, 0.128] and IL-6 (0.017 ln pg/mL; 95% CI −0.093, 0.128); the participants in the High-High group had a significantly lower level of adjusted CRP concentration (−0.279 ln mg/L; 95% CI: −0.434, −0.125) and similarly lower IL-6 concentration (−0.129 ln pg/mL; 95% CI −0.236, −0.023) . Life-course SEP is related to the level of CRP and IL-6 in older age. Our data support the notion that life-course SEP predicts inflammatory markers in older age. Low SEP in childhood is related to elevated inflammatory markers in older age. Even after the transition from low SEP in childhood to high SEP in older age, the risk remains. Further study on SEP and inflammation-related disease is warranted.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
5
作者：
Goldman, Noreen;Glei, Dana A.;Weinstein, Maxine
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Weinstein, Maxine
影响因子：
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作者：
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Weinstein, Maxine
影响因子：
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作者：
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影响因子：
3.3
作者：
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通讯作者：
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