Basal ganglia volume in unmedicated patients with schizophrenia is associated with treatment response to antipsychotic medication.
Basal ganglia volume in unmedicated patients with schizophrenia is associated with treatment response to antipsychotic medication.
复制标题
精神分裂症患者的基底神经节体积与对抗精神病药的治疗反应有关。
DOI：
10.1016/j.pscychresns.2013.10.002
复制
发表时间：
2014-01-30
影响因子：
11.3
通讯作者：
Lahti AC
中科院分区：
文献类型：
--
作者：
Hutcheson NL;Clark DG;Bolding MS;White DM;Lahti AC
我们调查了未用药的精神分裂症患者基底神经节体积与非典型抗精神病药物利培酮治疗反应之间的关系。基底神经节体积包括双侧尾状核、壳核和苍白球，并使用Freesurfer自动分割管道在23例受试者中进行测量。此外，基线症状的严重程度，疾病的持续时间，年龄，性别，停药的时间，和暴露于先前的抗精神病药物进行了测量。治疗反应与双侧基底神经节的所有三个区域（尾状核、壳核和苍白球）、基线症状严重程度、病程和年龄显著相关，但与性别、停药时间或既往抗精神病药物暴露无关。尾状核体积是基底神经节区域，表现出与治疗反应的最强相关性，并与患者年龄呈显著负相关。尾状核体积与任何其他指标均无显著相关性。我们证明了一个新的发现，尾状核体积解释了在利培酮药物治疗6周的过程中，即使在控制基线症状严重程度和疾病持续时间的治疗反应的差异显着量。
We investigated the relationship between basal ganglia volume and treatment response to the atypical antipsychotic medication risperidone in unmedicated patients with schizophrenia. Basal ganglia volumes included the bilateral caudate, putamen, and pallidum and were measured using the Freesurfer automated segmentation pipeline in 23 subjects. Also, baseline symptom severity, duration of illness, age, gender, time off medication, and exposure to previous antipsychotic were measured. Treatment response was significantly correlated with all three regions of the bilateral basal ganglia (caudate, putamen, and pallidum), baseline symptom severity, duration of illness, and age but not gender, time off antipsychotic medication, or exposure to previous antipsychotic medication. The caudate volume was the basal ganglia region that demonstrated the strongest correlation with treatment response and was significantly negatively correlated with patient age. Caudate volume was not significantly correlated with any other measure. We demonstrated a novel finding that the caudate volume explains a significant amount of the variance in treatment response over the course of six-weeks of risperidone pharmacotherapy even when controlling for baseline symptom severity and duration of illness.
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